The Non-Survival Effects of Glial Cell Line-Derived Neurotrophic Factor on Neural Cells
Glial cell line-derived neurotrophic factor (GDNF) was first characterized as a survival-promoting molecule for dopaminergic neurons (DANs). Afterwards, other cells were also discovered to respond to GDNF not only as a survival factor but also as a protein supporting other cellular functions, such a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-08-01
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| Series: | Frontiers in Molecular Neuroscience |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fnmol.2017.00258/full |
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| author | Daniel Cortés Daniel Cortés Oscar A. Carballo-Molina Oscar A. Carballo-Molina María José Castellanos-Montiel María José Castellanos-Montiel Iván Velasco Iván Velasco |
| author_facet | Daniel Cortés Daniel Cortés Oscar A. Carballo-Molina Oscar A. Carballo-Molina María José Castellanos-Montiel María José Castellanos-Montiel Iván Velasco Iván Velasco |
| author_sort | Daniel Cortés |
| collection | DOAJ |
| description | Glial cell line-derived neurotrophic factor (GDNF) was first characterized as a survival-promoting molecule for dopaminergic neurons (DANs). Afterwards, other cells were also discovered to respond to GDNF not only as a survival factor but also as a protein supporting other cellular functions, such as proliferation, differentiation, maturation, neurite outgrowth and other phenomena that have been less studied than survival and are now more extendedly described here in this review article. During development, GDNF favors the commitment of neural precursors towards dopaminergic, motor, enteric and adrenal neurons; in addition, it enhances the axonal growth of some of these neurons. GDNF also induces the acquisition of a dopaminergic phenotype by increasing the expression of Tyrosine Hydroxylase (TH), Nurr1 and other proteins that confer this identity and promote further dendritic and electrical maturation. In motor neurons (MNs), GDNF not only promotes proliferation and maturation but also participates in regenerating damaged axons and modulates the neuromuscular junction (NMJ) at both presynaptic and postsynaptic levels. Moreover, GDNF modulates the rate of neuroblastoma (NB) and glioblastoma cancer cell proliferation. Additionally, the presence or absence of GDNF has been correlated with conditions such as depression, pain, muscular soreness, etc. Although, the precise role of GDNF is unknown, it extends beyond a survival effect. The understanding of the complete range of properties of this trophic molecule will allow us to investigate its broad mechanisms of action to accelerate and/or improve therapies for the aforementioned pathological conditions. |
| first_indexed | 2024-04-13T07:03:44Z |
| format | Article |
| id | doaj.art-cfd93d1ea9ce4c468b6fc0e1048617e7 |
| institution | Directory Open Access Journal |
| issn | 1662-5099 |
| language | English |
| last_indexed | 2024-04-13T07:03:44Z |
| publishDate | 2017-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Neuroscience |
| spelling | doaj.art-cfd93d1ea9ce4c468b6fc0e1048617e72022-12-22T02:57:03ZengFrontiers Media S.A.Frontiers in Molecular Neuroscience1662-50992017-08-011010.3389/fnmol.2017.00258279895The Non-Survival Effects of Glial Cell Line-Derived Neurotrophic Factor on Neural CellsDaniel Cortés0Daniel Cortés1Oscar A. Carballo-Molina2Oscar A. Carballo-Molina3María José Castellanos-Montiel4María José Castellanos-Montiel5Iván Velasco6Iván Velasco7Instituto de Fisiología Celular—Neurociencias, Universidad Nacional Autónoma de MéxicoMéxico City, MexicoLaboratorio de Reprogramación Celular del IFC-UNAM, Instituto Nacional de Neurología y NeurologíaMéxico City, MexicoInstituto de Fisiología Celular—Neurociencias, Universidad Nacional Autónoma de MéxicoMéxico City, MexicoLaboratorio de Reprogramación Celular del IFC-UNAM, Instituto Nacional de Neurología y NeurologíaMéxico City, MexicoInstituto de Fisiología Celular—Neurociencias, Universidad Nacional Autónoma de MéxicoMéxico City, MexicoLaboratorio de Reprogramación Celular del IFC-UNAM, Instituto Nacional de Neurología y NeurologíaMéxico City, MexicoInstituto de Fisiología Celular—Neurociencias, Universidad Nacional Autónoma de MéxicoMéxico City, MexicoLaboratorio de Reprogramación Celular del IFC-UNAM, Instituto Nacional de Neurología y NeurologíaMéxico City, MexicoGlial cell line-derived neurotrophic factor (GDNF) was first characterized as a survival-promoting molecule for dopaminergic neurons (DANs). Afterwards, other cells were also discovered to respond to GDNF not only as a survival factor but also as a protein supporting other cellular functions, such as proliferation, differentiation, maturation, neurite outgrowth and other phenomena that have been less studied than survival and are now more extendedly described here in this review article. During development, GDNF favors the commitment of neural precursors towards dopaminergic, motor, enteric and adrenal neurons; in addition, it enhances the axonal growth of some of these neurons. GDNF also induces the acquisition of a dopaminergic phenotype by increasing the expression of Tyrosine Hydroxylase (TH), Nurr1 and other proteins that confer this identity and promote further dendritic and electrical maturation. In motor neurons (MNs), GDNF not only promotes proliferation and maturation but also participates in regenerating damaged axons and modulates the neuromuscular junction (NMJ) at both presynaptic and postsynaptic levels. Moreover, GDNF modulates the rate of neuroblastoma (NB) and glioblastoma cancer cell proliferation. Additionally, the presence or absence of GDNF has been correlated with conditions such as depression, pain, muscular soreness, etc. Although, the precise role of GDNF is unknown, it extends beyond a survival effect. The understanding of the complete range of properties of this trophic molecule will allow us to investigate its broad mechanisms of action to accelerate and/or improve therapies for the aforementioned pathological conditions.http://journal.frontiersin.org/article/10.3389/fnmol.2017.00258/fullneurogenesiselectrophysiological maturationmotor neurondopaminergic neuronsenteric nervous systempain |
| spellingShingle | Daniel Cortés Daniel Cortés Oscar A. Carballo-Molina Oscar A. Carballo-Molina María José Castellanos-Montiel María José Castellanos-Montiel Iván Velasco Iván Velasco The Non-Survival Effects of Glial Cell Line-Derived Neurotrophic Factor on Neural Cells Frontiers in Molecular Neuroscience neurogenesis electrophysiological maturation motor neuron dopaminergic neurons enteric nervous system pain |
| title | The Non-Survival Effects of Glial Cell Line-Derived Neurotrophic Factor on Neural Cells |
| title_full | The Non-Survival Effects of Glial Cell Line-Derived Neurotrophic Factor on Neural Cells |
| title_fullStr | The Non-Survival Effects of Glial Cell Line-Derived Neurotrophic Factor on Neural Cells |
| title_full_unstemmed | The Non-Survival Effects of Glial Cell Line-Derived Neurotrophic Factor on Neural Cells |
| title_short | The Non-Survival Effects of Glial Cell Line-Derived Neurotrophic Factor on Neural Cells |
| title_sort | non survival effects of glial cell line derived neurotrophic factor on neural cells |
| topic | neurogenesis electrophysiological maturation motor neuron dopaminergic neurons enteric nervous system pain |
| url | http://journal.frontiersin.org/article/10.3389/fnmol.2017.00258/full |
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