Flavonoids—Natural Gifts to Promote Health and Longevity
The aging of mammals is accompanied by the progressive atrophy of tissues and organs and the accumulation of random damage to macromolecular DNA, protein, and lipids. Flavonoids have excellent antioxidant, anti-inflammatory, and neuroprotective effects. Recent studies have shown that flavonoids can...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-02-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/4/2176 |
| _version_ | 1797479338182967296 |
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| author | Xiaolan Fan Ziqiang Fan Ziyue Yang Tiantian Huang Yingdong Tong Deying Yang Xueping Mao Mingyao Yang |
| author_facet | Xiaolan Fan Ziqiang Fan Ziyue Yang Tiantian Huang Yingdong Tong Deying Yang Xueping Mao Mingyao Yang |
| author_sort | Xiaolan Fan |
| collection | DOAJ |
| description | The aging of mammals is accompanied by the progressive atrophy of tissues and organs and the accumulation of random damage to macromolecular DNA, protein, and lipids. Flavonoids have excellent antioxidant, anti-inflammatory, and neuroprotective effects. Recent studies have shown that flavonoids can delay aging and prolong a healthy lifespan by eliminating senescent cells, inhibiting senescence-related secretion phenotypes (SASPs), and maintaining metabolic homeostasis. However, only a few systematic studies have described flavonoids in clinical treatment for anti-aging, which needs to be explored further. This review first highlights the association between aging and macromolecular damage. Then, we discuss advances in the role of flavonoid molecules in prolonging the health span and lifespan of organisms. This study may provide crucial information for drug design and developmental and clinical applications based on flavonoids. |
| first_indexed | 2024-03-09T21:44:26Z |
| format | Article |
| id | doaj.art-cfda29f848de416aa41753c1a32f4f6c |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T21:44:26Z |
| publishDate | 2022-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-cfda29f848de416aa41753c1a32f4f6c2023-11-23T20:21:09ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-02-01234217610.3390/ijms23042176Flavonoids—Natural Gifts to Promote Health and LongevityXiaolan Fan0Ziqiang Fan1Ziyue Yang2Tiantian Huang3Yingdong Tong4Deying Yang5Xueping Mao6Mingyao Yang7Institute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, ChinaInstitute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, ChinaInstitute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, ChinaInstitute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, ChinaInstitute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, ChinaInstitute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, ChinaInstitute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, ChinaInstitute of Animal Genetics and Breeding, Sichuan Agricultural University, Chengdu 611130, ChinaThe aging of mammals is accompanied by the progressive atrophy of tissues and organs and the accumulation of random damage to macromolecular DNA, protein, and lipids. Flavonoids have excellent antioxidant, anti-inflammatory, and neuroprotective effects. Recent studies have shown that flavonoids can delay aging and prolong a healthy lifespan by eliminating senescent cells, inhibiting senescence-related secretion phenotypes (SASPs), and maintaining metabolic homeostasis. However, only a few systematic studies have described flavonoids in clinical treatment for anti-aging, which needs to be explored further. This review first highlights the association between aging and macromolecular damage. Then, we discuss advances in the role of flavonoid molecules in prolonging the health span and lifespan of organisms. This study may provide crucial information for drug design and developmental and clinical applications based on flavonoids.https://www.mdpi.com/1422-0067/23/4/2176flavonoidsmacromolecular damagehealth spanaging |
| spellingShingle | Xiaolan Fan Ziqiang Fan Ziyue Yang Tiantian Huang Yingdong Tong Deying Yang Xueping Mao Mingyao Yang Flavonoids—Natural Gifts to Promote Health and Longevity International Journal of Molecular Sciences flavonoids macromolecular damage health span aging |
| title | Flavonoids—Natural Gifts to Promote Health and Longevity |
| title_full | Flavonoids—Natural Gifts to Promote Health and Longevity |
| title_fullStr | Flavonoids—Natural Gifts to Promote Health and Longevity |
| title_full_unstemmed | Flavonoids—Natural Gifts to Promote Health and Longevity |
| title_short | Flavonoids—Natural Gifts to Promote Health and Longevity |
| title_sort | flavonoids natural gifts to promote health and longevity |
| topic | flavonoids macromolecular damage health span aging |
| url | https://www.mdpi.com/1422-0067/23/4/2176 |
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