Nausea control in mild head trauma patients: Effectiveness of metoclopramide and ondansetron in the emergency department in a double-blind study
Background: Mild head trauma often causes several complications and disabilities including nausea and vomiting in hospitalized people. The aim of the present study was to compare the effectiveness of metoclopramide and ondansetron, and compare it with placebo to control nausea in the patients with m...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Babol University of Medical Sciences
2022-09-01
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| Series: | Caspian Journal of Internal Medicine |
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| Online Access: | http://caspjim.com/article-1-2835-en.html |
| _version_ | 1798046281811099648 |
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| author | Hamideh Feiz Disfani Mostafa Kamandi Seyyedeh Bahareh Hoseini Narges Shirazi Maryam Panahi |
| author_facet | Hamideh Feiz Disfani Mostafa Kamandi Seyyedeh Bahareh Hoseini Narges Shirazi Maryam Panahi |
| author_sort | Hamideh Feiz Disfani |
| collection | DOAJ |
| description | Background: Mild head trauma often causes several complications and disabilities including nausea and vomiting in hospitalized people. The aim of the present study was to compare the effectiveness of metoclopramide and ondansetron, and compare it with placebo to control nausea in the patients with mild head trauma admitted to the emergency department.
Methods: This is a randomized double-blind placebo-controlled clinical trial conducted on the patients with mild head trauma and normal brain CT scans who were admitted to the emergency department within 24 hours after the injury. The subjects were randomly divided into three groups of ondansetron (n= 41), metoclopramide (n= 44), and placebo (n= 39), and the severity of nausea and vomiting was assessed using the visual analogue scale (VAS).
Results: A total of 124 patients with mild head trauma were included in the study. The assessment of the VAS scores during the study showed that over time, the patients in all three groups had reduced nausea (p<0.01). On the other hand, the percentage change of the VAS score indicated that metoclopramide and ondansetron had the greatest changes (46.97% and 66.90%, respectively) within 15 and 30 minutes after the injection, respectively.
Conclusion: The results of the present study showed that ondansetron and metoclopramide had similar effects on nausea in the patients with mild head trauma. However, metoclopramide was most effective in 15 minutes and ondansetron in 30 minutes after the injection. |
| first_indexed | 2024-04-11T23:35:08Z |
| format | Article |
| id | doaj.art-cfdb9baffbee467bae9d5f13dd16b269 |
| institution | Directory Open Access Journal |
| issn | 2008-6164 2008-6172 |
| language | English |
| last_indexed | 2024-04-11T23:35:08Z |
| publishDate | 2022-09-01 |
| publisher | Babol University of Medical Sciences |
| record_format | Article |
| series | Caspian Journal of Internal Medicine |
| spelling | doaj.art-cfdb9baffbee467bae9d5f13dd16b2692022-12-22T03:56:59ZengBabol University of Medical SciencesCaspian Journal of Internal Medicine2008-61642008-61722022-09-01134699704Nausea control in mild head trauma patients: Effectiveness of metoclopramide and ondansetron in the emergency department in a double-blind studyHamideh Feiz Disfani0Mostafa Kamandi1Seyyedeh Bahareh Hoseini2Narges Shirazi3Maryam Panahi4 Department of Emergency Medicine, Faculty of medicine, Mashhad University of Medical Sciences, Mashhad, Iran Department of Hematology Oncology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Department of Emergency Medicine, Faculty of medicine, Mashhad University of Medical Sciences, Mashhad, Iran Department of Emergency Medicine, Faculty of medicine, Mashhad University of Medical Sciences, Mashhad, Iran Department of Emergency Medicine, Faculty of medicine, Mashhad University of Medical Sciences, Mashhad, Iran Background: Mild head trauma often causes several complications and disabilities including nausea and vomiting in hospitalized people. The aim of the present study was to compare the effectiveness of metoclopramide and ondansetron, and compare it with placebo to control nausea in the patients with mild head trauma admitted to the emergency department. Methods: This is a randomized double-blind placebo-controlled clinical trial conducted on the patients with mild head trauma and normal brain CT scans who were admitted to the emergency department within 24 hours after the injury. The subjects were randomly divided into three groups of ondansetron (n= 41), metoclopramide (n= 44), and placebo (n= 39), and the severity of nausea and vomiting was assessed using the visual analogue scale (VAS). Results: A total of 124 patients with mild head trauma were included in the study. The assessment of the VAS scores during the study showed that over time, the patients in all three groups had reduced nausea (p<0.01). On the other hand, the percentage change of the VAS score indicated that metoclopramide and ondansetron had the greatest changes (46.97% and 66.90%, respectively) within 15 and 30 minutes after the injection, respectively. Conclusion: The results of the present study showed that ondansetron and metoclopramide had similar effects on nausea in the patients with mild head trauma. However, metoclopramide was most effective in 15 minutes and ondansetron in 30 minutes after the injection.http://caspjim.com/article-1-2835-en.htmlmild head traumanauseavomitingondansetronmetoclopramide |
| spellingShingle | Hamideh Feiz Disfani Mostafa Kamandi Seyyedeh Bahareh Hoseini Narges Shirazi Maryam Panahi Nausea control in mild head trauma patients: Effectiveness of metoclopramide and ondansetron in the emergency department in a double-blind study Caspian Journal of Internal Medicine mild head trauma nausea vomiting ondansetron metoclopramide |
| title | Nausea control in mild head trauma patients: Effectiveness of metoclopramide and ondansetron in the emergency department in a double-blind study |
| title_full | Nausea control in mild head trauma patients: Effectiveness of metoclopramide and ondansetron in the emergency department in a double-blind study |
| title_fullStr | Nausea control in mild head trauma patients: Effectiveness of metoclopramide and ondansetron in the emergency department in a double-blind study |
| title_full_unstemmed | Nausea control in mild head trauma patients: Effectiveness of metoclopramide and ondansetron in the emergency department in a double-blind study |
| title_short | Nausea control in mild head trauma patients: Effectiveness of metoclopramide and ondansetron in the emergency department in a double-blind study |
| title_sort | nausea control in mild head trauma patients effectiveness of metoclopramide and ondansetron in the emergency department in a double blind study |
| topic | mild head trauma nausea vomiting ondansetron metoclopramide |
| url | http://caspjim.com/article-1-2835-en.html |
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