Combined Use of Antimicrobial Peptides with Antiseptics against Multidrug-Resistant Bacteria: Pros and Cons
Antimicrobial peptides (AMPs) are acknowledged as a promising template for designing new antimicrobials. At the same time, existing toxicity issues and limitations in their pharmacokinetics make topical application one of the less complicated routes to put AMPs-based therapeutics into actual medical...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/15/1/291 |
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| author | Maria S. Zharkova Aleksey S. Komlev Tatiana A. Filatenkova Maria S. Sukhareva Elizaveta V. Vladimirova Andrey S. Trulioff Dmitriy S. Orlov Alexander V. Dmitriev Anna G. Afinogenova Anna A. Spiridonova Olga V. Shamova |
| author_facet | Maria S. Zharkova Aleksey S. Komlev Tatiana A. Filatenkova Maria S. Sukhareva Elizaveta V. Vladimirova Andrey S. Trulioff Dmitriy S. Orlov Alexander V. Dmitriev Anna G. Afinogenova Anna A. Spiridonova Olga V. Shamova |
| author_sort | Maria S. Zharkova |
| collection | DOAJ |
| description | Antimicrobial peptides (AMPs) are acknowledged as a promising template for designing new antimicrobials. At the same time, existing toxicity issues and limitations in their pharmacokinetics make topical application one of the less complicated routes to put AMPs-based therapeutics into actual medical practice. Antiseptics are one of the common components for topical treatment potent against antibiotic-resistant pathogens but often with toxicity limitations of their own. Thus, the interaction of AMPs and antiseptics is an interesting topic that is also less explored than combined action of AMPs and antibiotics. Herein, we analyzed antibacterial, antibiofilm, and cytotoxic activity of combinations of both membranolytic and non-membranolytic AMPs with a number of antiseptic agents. Fractional concentration indices were used as a measure of possible effective concentration reduction achievable due to combined application. Cases of both synergistic and antagonistic interaction with certain antiseptics and surfactants were identified, and trends in the occurrence of these types of interaction were discussed. The data may be of use for AMP-based drug development and suggest that the topic requires further attention for successfully integrating AMPs-based products in the context of complex treatment. AMP/antiseptic combinations show promise for creating topical formulations with improved activity, lowered toxicity, and, presumably, decreased chances of inducing bacterial resistance. However, careful assessment is required to avoid AMP neutralization by certain antiseptic classes in either complex drug design or AMP application alongside other therapeutics/care products. |
| first_indexed | 2024-03-09T11:26:57Z |
| format | Article |
| id | doaj.art-cfdbbe8b0e774a4f95e10fe1a4eb140e |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T11:26:57Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-cfdbbe8b0e774a4f95e10fe1a4eb140e2023-12-01T00:00:26ZengMDPI AGPharmaceutics1999-49232023-01-0115129110.3390/pharmaceutics15010291Combined Use of Antimicrobial Peptides with Antiseptics against Multidrug-Resistant Bacteria: Pros and ConsMaria S. Zharkova0Aleksey S. Komlev1Tatiana A. Filatenkova2Maria S. Sukhareva3Elizaveta V. Vladimirova4Andrey S. Trulioff5Dmitriy S. Orlov6Alexander V. Dmitriev7Anna G. Afinogenova8Anna A. Spiridonova9Olga V. Shamova10Institute of Experimental Medicine, WCRC “Center for Personalized Medicine”, 12 Academic Pavlov Street, St. Petersburg 197022, RussiaInstitute of Experimental Medicine, WCRC “Center for Personalized Medicine”, 12 Academic Pavlov Street, St. Petersburg 197022, RussiaInstitute of Experimental Medicine, WCRC “Center for Personalized Medicine”, 12 Academic Pavlov Street, St. Petersburg 197022, RussiaInstitute of Experimental Medicine, WCRC “Center for Personalized Medicine”, 12 Academic Pavlov Street, St. Petersburg 197022, RussiaInstitute of Experimental Medicine, WCRC “Center for Personalized Medicine”, 12 Academic Pavlov Street, St. Petersburg 197022, RussiaInstitute of Experimental Medicine, WCRC “Center for Personalized Medicine”, 12 Academic Pavlov Street, St. Petersburg 197022, RussiaInstitute of Experimental Medicine, WCRC “Center for Personalized Medicine”, 12 Academic Pavlov Street, St. Petersburg 197022, RussiaInstitute of Experimental Medicine, WCRC “Center for Personalized Medicine”, 12 Academic Pavlov Street, St. Petersburg 197022, RussiaSt. Petersburg Pasteur Institute, 14 Mira Street, St. Petersburg 197101, RussiaDepartment of Clinical Microbiology, Pavlov First Saint Petersburg State Medical University, 6/8 Lev Tolstoy Street, St. Petersburg 197022, RussiaInstitute of Experimental Medicine, WCRC “Center for Personalized Medicine”, 12 Academic Pavlov Street, St. Petersburg 197022, RussiaAntimicrobial peptides (AMPs) are acknowledged as a promising template for designing new antimicrobials. At the same time, existing toxicity issues and limitations in their pharmacokinetics make topical application one of the less complicated routes to put AMPs-based therapeutics into actual medical practice. Antiseptics are one of the common components for topical treatment potent against antibiotic-resistant pathogens but often with toxicity limitations of their own. Thus, the interaction of AMPs and antiseptics is an interesting topic that is also less explored than combined action of AMPs and antibiotics. Herein, we analyzed antibacterial, antibiofilm, and cytotoxic activity of combinations of both membranolytic and non-membranolytic AMPs with a number of antiseptic agents. Fractional concentration indices were used as a measure of possible effective concentration reduction achievable due to combined application. Cases of both synergistic and antagonistic interaction with certain antiseptics and surfactants were identified, and trends in the occurrence of these types of interaction were discussed. The data may be of use for AMP-based drug development and suggest that the topic requires further attention for successfully integrating AMPs-based products in the context of complex treatment. AMP/antiseptic combinations show promise for creating topical formulations with improved activity, lowered toxicity, and, presumably, decreased chances of inducing bacterial resistance. However, careful assessment is required to avoid AMP neutralization by certain antiseptic classes in either complex drug design or AMP application alongside other therapeutics/care products.https://www.mdpi.com/1999-4923/15/1/291antimicrobial peptidesantisepticscombined usedrug-resistant bacteriaantibacterial actionbiofilms |
| spellingShingle | Maria S. Zharkova Aleksey S. Komlev Tatiana A. Filatenkova Maria S. Sukhareva Elizaveta V. Vladimirova Andrey S. Trulioff Dmitriy S. Orlov Alexander V. Dmitriev Anna G. Afinogenova Anna A. Spiridonova Olga V. Shamova Combined Use of Antimicrobial Peptides with Antiseptics against Multidrug-Resistant Bacteria: Pros and Cons Pharmaceutics antimicrobial peptides antiseptics combined use drug-resistant bacteria antibacterial action biofilms |
| title | Combined Use of Antimicrobial Peptides with Antiseptics against Multidrug-Resistant Bacteria: Pros and Cons |
| title_full | Combined Use of Antimicrobial Peptides with Antiseptics against Multidrug-Resistant Bacteria: Pros and Cons |
| title_fullStr | Combined Use of Antimicrobial Peptides with Antiseptics against Multidrug-Resistant Bacteria: Pros and Cons |
| title_full_unstemmed | Combined Use of Antimicrobial Peptides with Antiseptics against Multidrug-Resistant Bacteria: Pros and Cons |
| title_short | Combined Use of Antimicrobial Peptides with Antiseptics against Multidrug-Resistant Bacteria: Pros and Cons |
| title_sort | combined use of antimicrobial peptides with antiseptics against multidrug resistant bacteria pros and cons |
| topic | antimicrobial peptides antiseptics combined use drug-resistant bacteria antibacterial action biofilms |
| url | https://www.mdpi.com/1999-4923/15/1/291 |
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