Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease
Abstract Inflammatory bowel disease (IBD), which mainly includes ulcerative colitis (UC) and Crohn's disease (CD), is a group of chronic bowel diseases that are characterized by abdominal pain, diarrhea, and bloody stools. IBD is strongly associated with depression, and its patients have a high...
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| Format: | Article |
| Language: | English |
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BMC
2021-06-01
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| Series: | Journal of Neuroinflammation |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12974-021-02175-2 |
| _version_ | 1818571904778240000 |
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| author | Li-Ming Chen Chun-Hui Bao Yu Wu Shi-Hua Liang Di Wang Lu-Yi Wu Yan Huang Hui-Rong Liu Huan-Gan Wu |
| author_facet | Li-Ming Chen Chun-Hui Bao Yu Wu Shi-Hua Liang Di Wang Lu-Yi Wu Yan Huang Hui-Rong Liu Huan-Gan Wu |
| author_sort | Li-Ming Chen |
| collection | DOAJ |
| description | Abstract Inflammatory bowel disease (IBD), which mainly includes ulcerative colitis (UC) and Crohn's disease (CD), is a group of chronic bowel diseases that are characterized by abdominal pain, diarrhea, and bloody stools. IBD is strongly associated with depression, and its patients have a higher incidence of depression than the general population. Depression also adversely affects the quality of life and disease prognosis of patients with IBD. The tryptophan-kynurenine metabolic pathway degrades more than 90% of tryptophan (TRP) throughout the body, with indoleamine 2,3-dioxygenase (IDO), the key metabolic enzyme, being activated in the inflammatory environment. A series of metabolites of the pathway are neurologically active, among which kynerunic acid (KYNA) and quinolinic acid (QUIN) are molecules of great interest in recent studies on the mechanisms of inflammation-induced depression. In this review, the relationship between depression in IBD and the tryptophan-kynurenine metabolic pathway is overviewed in the light of recent publications. |
| first_indexed | 2024-12-14T18:50:25Z |
| format | Article |
| id | doaj.art-cfdc3464e622492595479647b25aef24 |
| institution | Directory Open Access Journal |
| issn | 1742-2094 |
| language | English |
| last_indexed | 2024-12-14T18:50:25Z |
| publishDate | 2021-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Neuroinflammation |
| spelling | doaj.art-cfdc3464e622492595479647b25aef242022-12-21T22:51:16ZengBMCJournal of Neuroinflammation1742-20942021-06-0118111310.1186/s12974-021-02175-2Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel diseaseLi-Ming Chen0Chun-Hui Bao1Yu Wu2Shi-Hua Liang3Di Wang4Lu-Yi Wu5Yan Huang6Hui-Rong Liu7Huan-Gan Wu8Yueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese MedicineYueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese MedicineYueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese MedicineFaculty of Economics and Business, University of GroningenYueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese MedicineKey Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese MedicineKey Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese MedicineYueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese MedicineYueyang Hospital of Integrated Chinese and Western Medicine, Shanghai University of Traditional Chinese MedicineAbstract Inflammatory bowel disease (IBD), which mainly includes ulcerative colitis (UC) and Crohn's disease (CD), is a group of chronic bowel diseases that are characterized by abdominal pain, diarrhea, and bloody stools. IBD is strongly associated with depression, and its patients have a higher incidence of depression than the general population. Depression also adversely affects the quality of life and disease prognosis of patients with IBD. The tryptophan-kynurenine metabolic pathway degrades more than 90% of tryptophan (TRP) throughout the body, with indoleamine 2,3-dioxygenase (IDO), the key metabolic enzyme, being activated in the inflammatory environment. A series of metabolites of the pathway are neurologically active, among which kynerunic acid (KYNA) and quinolinic acid (QUIN) are molecules of great interest in recent studies on the mechanisms of inflammation-induced depression. In this review, the relationship between depression in IBD and the tryptophan-kynurenine metabolic pathway is overviewed in the light of recent publications.https://doi.org/10.1186/s12974-021-02175-2Inflammatory bowel diseaseDepressionTryptophan-kynurenine metabolic pathwayIDOThe brain-gut axis |
| spellingShingle | Li-Ming Chen Chun-Hui Bao Yu Wu Shi-Hua Liang Di Wang Lu-Yi Wu Yan Huang Hui-Rong Liu Huan-Gan Wu Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease Journal of Neuroinflammation Inflammatory bowel disease Depression Tryptophan-kynurenine metabolic pathway IDO The brain-gut axis |
| title | Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease |
| title_full | Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease |
| title_fullStr | Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease |
| title_full_unstemmed | Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease |
| title_short | Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease |
| title_sort | tryptophan kynurenine metabolism a link between the gut and brain for depression in inflammatory bowel disease |
| topic | Inflammatory bowel disease Depression Tryptophan-kynurenine metabolic pathway IDO The brain-gut axis |
| url | https://doi.org/10.1186/s12974-021-02175-2 |
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