Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease

Tryptophan-kynurenine metabolism: a link between the gut and brain for depression in inflammatory bowel disease

Abstract Inflammatory bowel disease (IBD), which mainly includes ulcerative colitis (UC) and Crohn's disease (CD), is a group of chronic bowel diseases that are characterized by abdominal pain, diarrhea, and bloody stools. IBD is strongly associated with depression, and its patients have a high...

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Bibliographic Details
Main Authors: Li-Ming Chen, Chun-Hui Bao, Yu Wu, Shi-Hua Liang, Di Wang, Lu-Yi Wu, Yan Huang, Hui-Rong Liu, Huan-Gan Wu
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Journal of Neuroinflammation
Subjects:
Inflammatory bowel disease
Depression
Tryptophan-kynurenine metabolic pathway
IDO
The brain-gut axis
Online Access:https://doi.org/10.1186/s12974-021-02175-2

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