Genetic Adaptation and Acquisition of Macrolide Resistance in Haemophilus spp. during Persistent Respiratory Tract Colonization in Chronic Obstructive Pulmonary Disease (COPD) Patients Receiving Long-Term Azithromycin Treatment

Genetic Adaptation and Acquisition of Macrolide Resistance in Haemophilus spp. during Persistent Respiratory Tract Colonization in Chronic Obstructive Pulmonary Disease (COPD) Patients Receiving Long-Term Azithromycin Treatment

ABSTRACT Patients with chronic obstructive pulmonary disease (COPD) benefit from the immunomodulatory effect of azithromycin, but long-term administration may alter colonizing bacteria. Our goal was to identify changes in Haemophilus influenzae and Haemophilus parainfluenzae during azithromycin trea...

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Main Authors: Anna Carrera-Salinas, Aida González-Díaz, Rachel L. Ehrlich, Dàmaris Berbel, Fe Tubau, Xavier Pomares, Junkal Garmendia, M. Ángeles Domínguez, Carmen Ardanuy, Daniel Huertas, Alicia Marín, Conchita Montón, Joshua Chang Mell, Salud Santos, Sara Marti
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:Microbiology Spectrum
Subjects:
Haemophilus influenzae
Haemophilus parainfluenzae
persistence
macrolide resistance
azithromycin
adaptation
Online Access:https://journals.asm.org/doi/10.1128/spectrum.03860-22

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