Pan-Cancer Analysis Reveals PPRC1 as a Novel Prognostic Biomarker in Ovarian Cancer and Hepatocellular Carcinoma
<i>Background and Objectives</i>: As is well understood, peroxisome proliferator-activated receptor gamma cofactor-related 1 (<i>PPRC1</i>) plays a central role in the transcriptional control of the mitochondrial biogenesis and oxidative phosphorylation (OXPHOS) process, yet...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
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| Series: | Medicina |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1648-9144/59/4/784 |
| Summary: | <i>Background and Objectives</i>: As is well understood, peroxisome proliferator-activated receptor gamma cofactor-related 1 (<i>PPRC1</i>) plays a central role in the transcriptional control of the mitochondrial biogenesis and oxidative phosphorylation (OXPHOS) process, yet its critical role in pan-cancer remains unclear. <i>Materials and Methods</i>: In this paper, the expression levels of PPRC1 in different tumor tissues and corresponding adjacent normal tissues were analyzed based on four databases: The Genotype-Tissue Expression (GTEx), Cancer Cell Line Encyclopedia (CCLE), The Cancer Genome Atlas (TCGA), and Tumor Immune Estimation Resource (TIMER). Meanwhile, the prognostic value of <i>PPRC1</i> was inferred using Kaplan–Meier plotter and forest-plot studies. In addition, the correlation between <i>PPRC1</i> expression and tumor immune cell infiltration, immune checkpoints, and the tumor-stemness index was analyzed using TCGA and TIMER databases. <i>Results</i>: According to our findings, the expression level of <i>PPRC1</i> was found to be different in different cancer types and there was a positive correlation between <i>PPRC1</i> expression and prognosis in several tumor types. In addition, <i>PPRC1</i> expression was found to be significantly correlated with immune cell infiltration, immune checkpoints, and the tumor-stemness index in both ovarian and hepatocellular carcinoma. <i>Conclusions</i>: <i>PPRC1</i> demonstrated promising potential as a novel biomarker in pan-cancer due to its potential association with immune cell infiltration, expression of immune checkpoints, and the tumor-stemness index. |
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| ISSN: | 1010-660X 1648-9144 |