Pan-Cancer Analysis Reveals PPRC1 as a Novel Prognostic Biomarker in Ovarian Cancer and Hepatocellular Carcinoma
<i>Background and Objectives</i>: As is well understood, peroxisome proliferator-activated receptor gamma cofactor-related 1 (<i>PPRC1</i>) plays a central role in the transcriptional control of the mitochondrial biogenesis and oxidative phosphorylation (OXPHOS) process, yet...
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MDPI AG
2023-04-01
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| Series: | Medicina |
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| Online Access: | https://www.mdpi.com/1648-9144/59/4/784 |
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| author | Xingqiu Ruan Guoliang Cui Changyu Li Zhiguang Sun |
| author_facet | Xingqiu Ruan Guoliang Cui Changyu Li Zhiguang Sun |
| author_sort | Xingqiu Ruan |
| collection | DOAJ |
| description | <i>Background and Objectives</i>: As is well understood, peroxisome proliferator-activated receptor gamma cofactor-related 1 (<i>PPRC1</i>) plays a central role in the transcriptional control of the mitochondrial biogenesis and oxidative phosphorylation (OXPHOS) process, yet its critical role in pan-cancer remains unclear. <i>Materials and Methods</i>: In this paper, the expression levels of PPRC1 in different tumor tissues and corresponding adjacent normal tissues were analyzed based on four databases: The Genotype-Tissue Expression (GTEx), Cancer Cell Line Encyclopedia (CCLE), The Cancer Genome Atlas (TCGA), and Tumor Immune Estimation Resource (TIMER). Meanwhile, the prognostic value of <i>PPRC1</i> was inferred using Kaplan–Meier plotter and forest-plot studies. In addition, the correlation between <i>PPRC1</i> expression and tumor immune cell infiltration, immune checkpoints, and the tumor-stemness index was analyzed using TCGA and TIMER databases. <i>Results</i>: According to our findings, the expression level of <i>PPRC1</i> was found to be different in different cancer types and there was a positive correlation between <i>PPRC1</i> expression and prognosis in several tumor types. In addition, <i>PPRC1</i> expression was found to be significantly correlated with immune cell infiltration, immune checkpoints, and the tumor-stemness index in both ovarian and hepatocellular carcinoma. <i>Conclusions</i>: <i>PPRC1</i> demonstrated promising potential as a novel biomarker in pan-cancer due to its potential association with immune cell infiltration, expression of immune checkpoints, and the tumor-stemness index. |
| first_indexed | 2024-03-11T04:46:01Z |
| format | Article |
| id | doaj.art-cfdc75eb3935403a8f732f6ff9043645 |
| institution | Directory Open Access Journal |
| issn | 1010-660X 1648-9144 |
| language | English |
| last_indexed | 2024-03-11T04:46:01Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Medicina |
| spelling | doaj.art-cfdc75eb3935403a8f732f6ff90436452023-11-17T20:22:02ZengMDPI AGMedicina1010-660X1648-91442023-04-0159478410.3390/medicina59040784Pan-Cancer Analysis Reveals PPRC1 as a Novel Prognostic Biomarker in Ovarian Cancer and Hepatocellular CarcinomaXingqiu Ruan0Guoliang Cui1Changyu Li2Zhiguang Sun3Department of Gastroenterology, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210023, ChinaDepartment of Gastroenterology, The Second Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210023, ChinaDepartment of Rehabilitation Medicine, Red Cross Hospital of Yulin City, Yulin 537000, ChinaThe Second Clinical Medical Collegel, Nanjing University of Chinese Medicine, Nanjing 210023, China<i>Background and Objectives</i>: As is well understood, peroxisome proliferator-activated receptor gamma cofactor-related 1 (<i>PPRC1</i>) plays a central role in the transcriptional control of the mitochondrial biogenesis and oxidative phosphorylation (OXPHOS) process, yet its critical role in pan-cancer remains unclear. <i>Materials and Methods</i>: In this paper, the expression levels of PPRC1 in different tumor tissues and corresponding adjacent normal tissues were analyzed based on four databases: The Genotype-Tissue Expression (GTEx), Cancer Cell Line Encyclopedia (CCLE), The Cancer Genome Atlas (TCGA), and Tumor Immune Estimation Resource (TIMER). Meanwhile, the prognostic value of <i>PPRC1</i> was inferred using Kaplan–Meier plotter and forest-plot studies. In addition, the correlation between <i>PPRC1</i> expression and tumor immune cell infiltration, immune checkpoints, and the tumor-stemness index was analyzed using TCGA and TIMER databases. <i>Results</i>: According to our findings, the expression level of <i>PPRC1</i> was found to be different in different cancer types and there was a positive correlation between <i>PPRC1</i> expression and prognosis in several tumor types. In addition, <i>PPRC1</i> expression was found to be significantly correlated with immune cell infiltration, immune checkpoints, and the tumor-stemness index in both ovarian and hepatocellular carcinoma. <i>Conclusions</i>: <i>PPRC1</i> demonstrated promising potential as a novel biomarker in pan-cancer due to its potential association with immune cell infiltration, expression of immune checkpoints, and the tumor-stemness index.https://www.mdpi.com/1648-9144/59/4/784PPRC1pan-cancerprognosisimmune checkpointexpression |
| spellingShingle | Xingqiu Ruan Guoliang Cui Changyu Li Zhiguang Sun Pan-Cancer Analysis Reveals PPRC1 as a Novel Prognostic Biomarker in Ovarian Cancer and Hepatocellular Carcinoma Medicina PPRC1 pan-cancer prognosis immune checkpoint expression |
| title | Pan-Cancer Analysis Reveals PPRC1 as a Novel Prognostic Biomarker in Ovarian Cancer and Hepatocellular Carcinoma |
| title_full | Pan-Cancer Analysis Reveals PPRC1 as a Novel Prognostic Biomarker in Ovarian Cancer and Hepatocellular Carcinoma |
| title_fullStr | Pan-Cancer Analysis Reveals PPRC1 as a Novel Prognostic Biomarker in Ovarian Cancer and Hepatocellular Carcinoma |
| title_full_unstemmed | Pan-Cancer Analysis Reveals PPRC1 as a Novel Prognostic Biomarker in Ovarian Cancer and Hepatocellular Carcinoma |
| title_short | Pan-Cancer Analysis Reveals PPRC1 as a Novel Prognostic Biomarker in Ovarian Cancer and Hepatocellular Carcinoma |
| title_sort | pan cancer analysis reveals pprc1 as a novel prognostic biomarker in ovarian cancer and hepatocellular carcinoma |
| topic | PPRC1 pan-cancer prognosis immune checkpoint expression |
| url | https://www.mdpi.com/1648-9144/59/4/784 |
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