Human intracranial recordings reveal distinct cortical activity patterns during invasive and non-invasive vagus nerve stimulation
Abstract Vagus nerve stimulation (VNS) is being used increasingly to treat a wide array of diseases and disorders. This growth is driven in part by the putative ability to stimulate the nerve non-invasively. Despite decades of use and a rapidly expanding application space, we lack a complete underst...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2021-11-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-021-02307-x |
| _version_ | 1819014977739030528 |
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| author | William L. Schuerman Kirill V. Nourski Ariane E. Rhone Matthew A. Howard Edward F. Chang Matthew K. Leonard |
| author_facet | William L. Schuerman Kirill V. Nourski Ariane E. Rhone Matthew A. Howard Edward F. Chang Matthew K. Leonard |
| author_sort | William L. Schuerman |
| collection | DOAJ |
| description | Abstract Vagus nerve stimulation (VNS) is being used increasingly to treat a wide array of diseases and disorders. This growth is driven in part by the putative ability to stimulate the nerve non-invasively. Despite decades of use and a rapidly expanding application space, we lack a complete understanding of the acute effects of VNS on human cortical neurophysiology. Here, we investigated cortical responses to sub-perceptual threshold cervical implanted (iVNS) and transcutaneous auricular (taVNS) vagus nerve stimulation using intracranial neurophysiological recordings in human epilepsy patients. To understand the areas that are modulated by VNS and how they differ depending on invasiveness and stimulation parameters, we compared VNS-evoked neural activity across a range of stimulation modalities, frequencies, and amplitudes. Using comparable stimulation parameters, both iVNS and taVNS caused subtle changes in low-frequency power across broad cortical networks, which were not the same across modalities and were highly variable across participants. However, within at least some individuals, it may be possible to elicit similar responses across modalities using distinct sets of stimulation parameters. These results demonstrate that both invasive and non-invasive VNS cause evoked changes in activity across a set of highly distributed cortical networks that are relevant to a diverse array of clinical, rehabilitative, and enhancement applications. |
| first_indexed | 2024-12-21T02:24:25Z |
| format | Article |
| id | doaj.art-cfdfb19fe9e64d4e91f1e2017473f503 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-21T02:24:25Z |
| publishDate | 2021-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-cfdfb19fe9e64d4e91f1e2017473f5032022-12-21T19:19:03ZengNature PortfolioScientific Reports2045-23222021-11-0111111410.1038/s41598-021-02307-xHuman intracranial recordings reveal distinct cortical activity patterns during invasive and non-invasive vagus nerve stimulationWilliam L. Schuerman0Kirill V. Nourski1Ariane E. Rhone2Matthew A. Howard3Edward F. Chang4Matthew K. Leonard5Department of Neurological Surgery, University of California, San FranciscoDepartment of Neurosurgery, The University of Iowa, Roy J. and Lucille A. Carver College of MedicineDepartment of Neurosurgery, The University of Iowa, Roy J. and Lucille A. Carver College of MedicineDepartment of Neurosurgery, The University of Iowa, Roy J. and Lucille A. Carver College of MedicineDepartment of Neurological Surgery, University of California, San FranciscoDepartment of Neurological Surgery, University of California, San FranciscoAbstract Vagus nerve stimulation (VNS) is being used increasingly to treat a wide array of diseases and disorders. This growth is driven in part by the putative ability to stimulate the nerve non-invasively. Despite decades of use and a rapidly expanding application space, we lack a complete understanding of the acute effects of VNS on human cortical neurophysiology. Here, we investigated cortical responses to sub-perceptual threshold cervical implanted (iVNS) and transcutaneous auricular (taVNS) vagus nerve stimulation using intracranial neurophysiological recordings in human epilepsy patients. To understand the areas that are modulated by VNS and how they differ depending on invasiveness and stimulation parameters, we compared VNS-evoked neural activity across a range of stimulation modalities, frequencies, and amplitudes. Using comparable stimulation parameters, both iVNS and taVNS caused subtle changes in low-frequency power across broad cortical networks, which were not the same across modalities and were highly variable across participants. However, within at least some individuals, it may be possible to elicit similar responses across modalities using distinct sets of stimulation parameters. These results demonstrate that both invasive and non-invasive VNS cause evoked changes in activity across a set of highly distributed cortical networks that are relevant to a diverse array of clinical, rehabilitative, and enhancement applications.https://doi.org/10.1038/s41598-021-02307-x |
| spellingShingle | William L. Schuerman Kirill V. Nourski Ariane E. Rhone Matthew A. Howard Edward F. Chang Matthew K. Leonard Human intracranial recordings reveal distinct cortical activity patterns during invasive and non-invasive vagus nerve stimulation Scientific Reports |
| title | Human intracranial recordings reveal distinct cortical activity patterns during invasive and non-invasive vagus nerve stimulation |
| title_full | Human intracranial recordings reveal distinct cortical activity patterns during invasive and non-invasive vagus nerve stimulation |
| title_fullStr | Human intracranial recordings reveal distinct cortical activity patterns during invasive and non-invasive vagus nerve stimulation |
| title_full_unstemmed | Human intracranial recordings reveal distinct cortical activity patterns during invasive and non-invasive vagus nerve stimulation |
| title_short | Human intracranial recordings reveal distinct cortical activity patterns during invasive and non-invasive vagus nerve stimulation |
| title_sort | human intracranial recordings reveal distinct cortical activity patterns during invasive and non invasive vagus nerve stimulation |
| url | https://doi.org/10.1038/s41598-021-02307-x |
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