Retinoblastoma Tumor Suppressor Protein Roles in Epigenetic Regulation
Mutations that result in the loss of function of pRB were first identified in retinoblastoma and since then have been associated with the propagation of various forms of cancer. pRB is best known for its key role as a transcriptional regulator during cell cycle exit. Beyond the ability of pRB to reg...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Cancers |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2072-6694/12/10/2807 |
| _version_ | 1797552242946998272 |
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| author | Frederick Guzman Yasamin Fazeli Meagan Khuu Kelsey Salcido Sarah Singh Claudia A. Benavente |
| author_facet | Frederick Guzman Yasamin Fazeli Meagan Khuu Kelsey Salcido Sarah Singh Claudia A. Benavente |
| author_sort | Frederick Guzman |
| collection | DOAJ |
| description | Mutations that result in the loss of function of pRB were first identified in retinoblastoma and since then have been associated with the propagation of various forms of cancer. pRB is best known for its key role as a transcriptional regulator during cell cycle exit. Beyond the ability of pRB to regulate transcription of cell cycle progression genes, pRB can remodel chromatin to exert several of its other biological roles. In this review, we discuss the diverse functions of pRB in epigenetic regulation including nucleosome mobilization, histone modifications, DNA methylation and non-coding RNAs. |
| first_indexed | 2024-03-10T15:58:15Z |
| format | Article |
| id | doaj.art-cfe0485cf1b847f28d172c643a746dca |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-10T15:58:15Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-cfe0485cf1b847f28d172c643a746dca2023-11-20T15:33:18ZengMDPI AGCancers2072-66942020-09-011210280710.3390/cancers12102807Retinoblastoma Tumor Suppressor Protein Roles in Epigenetic RegulationFrederick Guzman0Yasamin Fazeli1Meagan Khuu2Kelsey Salcido3Sarah Singh4Claudia A. Benavente5Department of Pharmaceutical Sciences, University of California, 101 Theory #100, Irvine, CA 92617, USASchool of Biological Sciences, University of California, 5120 Natural Sciences II, Irvine, CA 92697, USASchool of Biological Sciences, University of California, 5120 Natural Sciences II, Irvine, CA 92697, USASchool of Biological Sciences, University of California, 5120 Natural Sciences II, Irvine, CA 92697, USASchool of Biological Sciences, University of California, 5120 Natural Sciences II, Irvine, CA 92697, USADepartment of Pharmaceutical Sciences, University of California, 101 Theory #100, Irvine, CA 92617, USAMutations that result in the loss of function of pRB were first identified in retinoblastoma and since then have been associated with the propagation of various forms of cancer. pRB is best known for its key role as a transcriptional regulator during cell cycle exit. Beyond the ability of pRB to regulate transcription of cell cycle progression genes, pRB can remodel chromatin to exert several of its other biological roles. In this review, we discuss the diverse functions of pRB in epigenetic regulation including nucleosome mobilization, histone modifications, DNA methylation and non-coding RNAs.https://www.mdpi.com/2072-6694/12/10/2807retinoblastomaRB1E2FepigeneticDNA methylationhistone modification |
| spellingShingle | Frederick Guzman Yasamin Fazeli Meagan Khuu Kelsey Salcido Sarah Singh Claudia A. Benavente Retinoblastoma Tumor Suppressor Protein Roles in Epigenetic Regulation Cancers retinoblastoma RB1 E2F epigenetic DNA methylation histone modification |
| title | Retinoblastoma Tumor Suppressor Protein Roles in Epigenetic Regulation |
| title_full | Retinoblastoma Tumor Suppressor Protein Roles in Epigenetic Regulation |
| title_fullStr | Retinoblastoma Tumor Suppressor Protein Roles in Epigenetic Regulation |
| title_full_unstemmed | Retinoblastoma Tumor Suppressor Protein Roles in Epigenetic Regulation |
| title_short | Retinoblastoma Tumor Suppressor Protein Roles in Epigenetic Regulation |
| title_sort | retinoblastoma tumor suppressor protein roles in epigenetic regulation |
| topic | retinoblastoma RB1 E2F epigenetic DNA methylation histone modification |
| url | https://www.mdpi.com/2072-6694/12/10/2807 |
| work_keys_str_mv | AT frederickguzman retinoblastomatumorsuppressorproteinrolesinepigeneticregulation AT yasaminfazeli retinoblastomatumorsuppressorproteinrolesinepigeneticregulation AT meagankhuu retinoblastomatumorsuppressorproteinrolesinepigeneticregulation AT kelseysalcido retinoblastomatumorsuppressorproteinrolesinepigeneticregulation AT sarahsingh retinoblastomatumorsuppressorproteinrolesinepigeneticregulation AT claudiaabenavente retinoblastomatumorsuppressorproteinrolesinepigeneticregulation |