Can Positron Emission Tomography and Computed Tomography Be a Substitute for Bone Marrow Biopsy in Detection of Bone Marrow Involvement in Patients with Hodgkin's or Non-Hodgkin's Lymphoma?
INTRODUCTION: Positron emission tomography and computed tomography (PET/CT) has become an important part of staging and treatment evaluation algorithms of lymphoma. We aimed to compare the results of PET/CT with bone marrow biopsy (BMB) with respect to bone marrow involvement (BMI) in patients with...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2015-07-01
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| Series: | Turkish Journal of Hematology |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-48254 |
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| author | Güven Çetin M. Ali Çıkrıkçıoğlu Tuba Özkan Cumali Karatoprak M. Cem Ar Ahmet Emre Eşkazan Mesut Ayer Abdullah Cerit Kübra Gözübenli Betül Börkü Uysal Simge Erdem Nurhan Ergül Gamze Tatar T. Fikret Çermik |
| author_facet | Güven Çetin M. Ali Çıkrıkçıoğlu Tuba Özkan Cumali Karatoprak M. Cem Ar Ahmet Emre Eşkazan Mesut Ayer Abdullah Cerit Kübra Gözübenli Betül Börkü Uysal Simge Erdem Nurhan Ergül Gamze Tatar T. Fikret Çermik |
| author_sort | Güven Çetin |
| collection | DOAJ |
| description | INTRODUCTION: Positron emission tomography and computed tomography (PET/CT) has become an important part of staging and treatment evaluation algorithms of lymphoma. We aimed to compare the results of PET/CT with bone marrow biopsy (BMB) with respect to bone marrow involvement (BMI) in patients with Hodgkin's lymphoma (HL) and aggressive non-Hodgkin's lymphoma (aNHL). METHODS: The medical files of a total of 297 patients diagnosed with HL or aNHL and followed at the hematology clinics of 3 major hospitals in İstanbul between 2008 and 2012 were screened retrospectively and 161 patients with classical HL and aNHL were included in the study. The patients were referred for PET/CT and BMB at the initial staging. BMB was performed as the reference standard for the evaluation of BMI. RESULTS: There were 61 (38%) HL and 100 (62%) aNHL patients. Concordant results were revealed between PET/CT and BMB in 126 patients (78%) (52 HL, 74 aNHL), 20 with positive PET/CT and BMB results and 106 with negative PET/CT and BMB results. There were discordant results in 35 patients (9 HL, 26 aNHL), 16 of them with positive BMB and negative PET/ CT results and 19 of them with negative BMB and positive PET/CT results. DISCUSSION AND CONCLUSION: We observed that PET/CT is effective to detect BMI, despite it alone not being sufficient to evaluate BMI in HL and aNHL. Bone marrow trephine biopsy and PET/CT should be considered as mutually complementary methods for detection of BMI in patients with lymphoma. In suspected focal involvement, combining biopsy and PET/CT might improve staging results. |
| first_indexed | 2024-04-10T11:03:30Z |
| format | Article |
| id | doaj.art-cfe1acd0ce6f40ea9ccff6e6f0792470 |
| institution | Directory Open Access Journal |
| issn | 1308-5263 |
| language | English |
| last_indexed | 2024-04-10T11:03:30Z |
| publishDate | 2015-07-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Turkish Journal of Hematology |
| spelling | doaj.art-cfe1acd0ce6f40ea9ccff6e6f07924702023-02-15T16:19:31ZengGalenos Publishing HouseTurkish Journal of Hematology1308-52632015-07-0132321321910.4274/tjh.2013.0336TJH-48254Can Positron Emission Tomography and Computed Tomography Be a Substitute for Bone Marrow Biopsy in Detection of Bone Marrow Involvement in Patients with Hodgkin's or Non-Hodgkin's Lymphoma?Güven Çetin0M. Ali Çıkrıkçıoğlu1Tuba Özkan2Cumali Karatoprak3M. Cem Ar4Ahmet Emre Eşkazan5Mesut Ayer6Abdullah Cerit7Kübra Gözübenli8Betül Börkü Uysal9Simge Erdem10Nurhan Ergül11Gamze Tatar12T. Fikret Çermik13Bezmialem Vakıf University Faculty Of Medicine, Department Of Internal Medicine, Division Of Hematology, İstanbul, TurkeyBezmialem Vakıf University Faculty Of Medicine, Department Of General Internal Medicine, İstanbul, TurkeyBezmialem Vakıf University Faculty Of Medicine, Department Of General Internal Medicine, İstanbul, TurkeyBezmialem Vakıf University Faculty Of Medicine, Department Of General Internal Medicine, İstanbul, Turkeyİstanbul University Cerrahpaşa Faculty Of Medicine, Department Of General Internal Medicine, Division Of Hematology, İstanbul, Turkeyİstanbul University Cerrahpaşa Faculty Of Medicine, Department Of General Internal Medicine, Division Of Hematology, İstanbul, Turkeyİstanbul Training and Research Hospital, Clinic of Hematology, İstanbul, Turkeyİstanbul Training and Research Hospital, Clinic of Internal Medicine, İstanbul, Turkeyİstanbul Training and Research Hospital, Clinic of Internal Medicine, İstanbul, Turkeyİstanbul Training and Research Hospital, Clinic of Internal Medicine, İstanbul, Turkeyİstanbul Training and Research Hospital, Clinic of Internal Medicine, İstanbul, Turkeyİstanbul Training and Research Hospital, Clinic of Nuclear Medicine, İstanbul, Turkeyİstanbul Training and Research Hospital, Clinic of Nuclear Medicine, İstanbul, Turkeyİstanbul Training and Research Hospital, Clinic of Nuclear Medicine, İstanbul, TurkeyINTRODUCTION: Positron emission tomography and computed tomography (PET/CT) has become an important part of staging and treatment evaluation algorithms of lymphoma. We aimed to compare the results of PET/CT with bone marrow biopsy (BMB) with respect to bone marrow involvement (BMI) in patients with Hodgkin's lymphoma (HL) and aggressive non-Hodgkin's lymphoma (aNHL). METHODS: The medical files of a total of 297 patients diagnosed with HL or aNHL and followed at the hematology clinics of 3 major hospitals in İstanbul between 2008 and 2012 were screened retrospectively and 161 patients with classical HL and aNHL were included in the study. The patients were referred for PET/CT and BMB at the initial staging. BMB was performed as the reference standard for the evaluation of BMI. RESULTS: There were 61 (38%) HL and 100 (62%) aNHL patients. Concordant results were revealed between PET/CT and BMB in 126 patients (78%) (52 HL, 74 aNHL), 20 with positive PET/CT and BMB results and 106 with negative PET/CT and BMB results. There were discordant results in 35 patients (9 HL, 26 aNHL), 16 of them with positive BMB and negative PET/ CT results and 19 of them with negative BMB and positive PET/CT results. DISCUSSION AND CONCLUSION: We observed that PET/CT is effective to detect BMI, despite it alone not being sufficient to evaluate BMI in HL and aNHL. Bone marrow trephine biopsy and PET/CT should be considered as mutually complementary methods for detection of BMI in patients with lymphoma. In suspected focal involvement, combining biopsy and PET/CT might improve staging results.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-48254positron emission tomographycomputed tomographybone marrow biopsyhodgkin's lymphomanon-hodgkin's lymphoma |
| spellingShingle | Güven Çetin M. Ali Çıkrıkçıoğlu Tuba Özkan Cumali Karatoprak M. Cem Ar Ahmet Emre Eşkazan Mesut Ayer Abdullah Cerit Kübra Gözübenli Betül Börkü Uysal Simge Erdem Nurhan Ergül Gamze Tatar T. Fikret Çermik Can Positron Emission Tomography and Computed Tomography Be a Substitute for Bone Marrow Biopsy in Detection of Bone Marrow Involvement in Patients with Hodgkin's or Non-Hodgkin's Lymphoma? Turkish Journal of Hematology positron emission tomography computed tomography bone marrow biopsy hodgkin's lymphoma non-hodgkin's lymphoma |
| title | Can Positron Emission Tomography and Computed Tomography Be a Substitute for Bone Marrow Biopsy in Detection of Bone Marrow Involvement in Patients with Hodgkin's or Non-Hodgkin's Lymphoma? |
| title_full | Can Positron Emission Tomography and Computed Tomography Be a Substitute for Bone Marrow Biopsy in Detection of Bone Marrow Involvement in Patients with Hodgkin's or Non-Hodgkin's Lymphoma? |
| title_fullStr | Can Positron Emission Tomography and Computed Tomography Be a Substitute for Bone Marrow Biopsy in Detection of Bone Marrow Involvement in Patients with Hodgkin's or Non-Hodgkin's Lymphoma? |
| title_full_unstemmed | Can Positron Emission Tomography and Computed Tomography Be a Substitute for Bone Marrow Biopsy in Detection of Bone Marrow Involvement in Patients with Hodgkin's or Non-Hodgkin's Lymphoma? |
| title_short | Can Positron Emission Tomography and Computed Tomography Be a Substitute for Bone Marrow Biopsy in Detection of Bone Marrow Involvement in Patients with Hodgkin's or Non-Hodgkin's Lymphoma? |
| title_sort | can positron emission tomography and computed tomography be a substitute for bone marrow biopsy in detection of bone marrow involvement in patients with hodgkin s or non hodgkin s lymphoma |
| topic | positron emission tomography computed tomography bone marrow biopsy hodgkin's lymphoma non-hodgkin's lymphoma |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=tjh&un=TJH-48254 |
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