Human rhinoviruses prevailed among children in the setting of wearing face masks in Shanghai, 2020
Abstract Background Human rhinovirus (HRV) is the predominant etiological agent of the common cold in children and adults. A recent study showed that the inhibitory effect of face masks on viral shedding of HRV was less prominent than that on other respiratory viruses. Considering that most Chinese...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-03-01
|
| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-022-07225-5 |
| _version_ | 1818315480184651776 |
|---|---|
| author | Ran Jia Lijuan Lu Shu Li Pengcheng Liu Menghua Xu Lingfeng Cao Liyun Su Jin Xu |
| author_facet | Ran Jia Lijuan Lu Shu Li Pengcheng Liu Menghua Xu Lingfeng Cao Liyun Su Jin Xu |
| author_sort | Ran Jia |
| collection | DOAJ |
| description | Abstract Background Human rhinovirus (HRV) is the predominant etiological agent of the common cold in children and adults. A recent study showed that the inhibitory effect of face masks on viral shedding of HRV was less prominent than that on other respiratory viruses. Considering that most Chinese people have worn face masks in public area since the outbreak of coronavirus disease 2019, we aimed to find out whether HRV prevailed among children in 2020 and demonstrate the details of the epidemiological features of HRV under such a special circumstance. Methods We summarized the incidences of various respiratory virus infections in patients who visited the Children’s Hospital of Fudan University during 2018–2020, and genotyped HRV positive nasopharyngeal specimens collected from 316 inpatients and 72 outpatients that visited the hospital in 2020. Results There was a major prevalence of HRV among children in the latter half of 2020, with a clear seasonality that HRV-As prevailed in summer while HRV-Cs in autumn. HRV-As were more prone to cause severe lower respiratory tract infections (LRTI), while HRV-Cs were closely associated with childhood wheezing. The predominant genotypes were A11, A28, A47, A82, A101, C40 and C43. Notably, A21, A82 and A101 took up larger proportions in severe cases than in non-severe cases. Conclusions Our findings described a major prevalence of HRVs among children in 2020, which highlight the unique transmitting pattern of HRV and help to narrow the targets for antiviral strategies. |
| first_indexed | 2024-12-13T09:06:12Z |
| format | Article |
| id | doaj.art-cfe2056efac843baa621fe18194e72ac |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-13T09:06:12Z |
| publishDate | 2022-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-cfe2056efac843baa621fe18194e72ac2022-12-21T23:53:03ZengBMCBMC Infectious Diseases1471-23342022-03-0122111210.1186/s12879-022-07225-5Human rhinoviruses prevailed among children in the setting of wearing face masks in Shanghai, 2020Ran Jia0Lijuan Lu1Shu Li2Pengcheng Liu3Menghua Xu4Lingfeng Cao5Liyun Su6Jin Xu7Department of Clinical Laboratory, Children’s Hospital of Fudan UniversityDepartment of Clinical Laboratory, Children’s Hospital of Fudan UniversitySchool of Laboratory Medicine and Life Sciences, Wenzhou Medical UniversityDepartment of Clinical Laboratory, Children’s Hospital of Fudan UniversityDepartment of Clinical Laboratory, Children’s Hospital of Fudan UniversityDepartment of Clinical Laboratory, Children’s Hospital of Fudan UniversityDepartment of Clinical Laboratory, Children’s Hospital of Fudan UniversityDepartment of Clinical Laboratory, Children’s Hospital of Fudan UniversityAbstract Background Human rhinovirus (HRV) is the predominant etiological agent of the common cold in children and adults. A recent study showed that the inhibitory effect of face masks on viral shedding of HRV was less prominent than that on other respiratory viruses. Considering that most Chinese people have worn face masks in public area since the outbreak of coronavirus disease 2019, we aimed to find out whether HRV prevailed among children in 2020 and demonstrate the details of the epidemiological features of HRV under such a special circumstance. Methods We summarized the incidences of various respiratory virus infections in patients who visited the Children’s Hospital of Fudan University during 2018–2020, and genotyped HRV positive nasopharyngeal specimens collected from 316 inpatients and 72 outpatients that visited the hospital in 2020. Results There was a major prevalence of HRV among children in the latter half of 2020, with a clear seasonality that HRV-As prevailed in summer while HRV-Cs in autumn. HRV-As were more prone to cause severe lower respiratory tract infections (LRTI), while HRV-Cs were closely associated with childhood wheezing. The predominant genotypes were A11, A28, A47, A82, A101, C40 and C43. Notably, A21, A82 and A101 took up larger proportions in severe cases than in non-severe cases. Conclusions Our findings described a major prevalence of HRVs among children in 2020, which highlight the unique transmitting pattern of HRV and help to narrow the targets for antiviral strategies.https://doi.org/10.1186/s12879-022-07225-5Human rhinovirusRespiratory tract infectionChildrenMolecular epidemiologyWheezing |
| spellingShingle | Ran Jia Lijuan Lu Shu Li Pengcheng Liu Menghua Xu Lingfeng Cao Liyun Su Jin Xu Human rhinoviruses prevailed among children in the setting of wearing face masks in Shanghai, 2020 BMC Infectious Diseases Human rhinovirus Respiratory tract infection Children Molecular epidemiology Wheezing |
| title | Human rhinoviruses prevailed among children in the setting of wearing face masks in Shanghai, 2020 |
| title_full | Human rhinoviruses prevailed among children in the setting of wearing face masks in Shanghai, 2020 |
| title_fullStr | Human rhinoviruses prevailed among children in the setting of wearing face masks in Shanghai, 2020 |
| title_full_unstemmed | Human rhinoviruses prevailed among children in the setting of wearing face masks in Shanghai, 2020 |
| title_short | Human rhinoviruses prevailed among children in the setting of wearing face masks in Shanghai, 2020 |
| title_sort | human rhinoviruses prevailed among children in the setting of wearing face masks in shanghai 2020 |
| topic | Human rhinovirus Respiratory tract infection Children Molecular epidemiology Wheezing |
| url | https://doi.org/10.1186/s12879-022-07225-5 |
| work_keys_str_mv | AT ranjia humanrhinovirusesprevailedamongchildreninthesettingofwearingfacemasksinshanghai2020 AT lijuanlu humanrhinovirusesprevailedamongchildreninthesettingofwearingfacemasksinshanghai2020 AT shuli humanrhinovirusesprevailedamongchildreninthesettingofwearingfacemasksinshanghai2020 AT pengchengliu humanrhinovirusesprevailedamongchildreninthesettingofwearingfacemasksinshanghai2020 AT menghuaxu humanrhinovirusesprevailedamongchildreninthesettingofwearingfacemasksinshanghai2020 AT lingfengcao humanrhinovirusesprevailedamongchildreninthesettingofwearingfacemasksinshanghai2020 AT liyunsu humanrhinovirusesprevailedamongchildreninthesettingofwearingfacemasksinshanghai2020 AT jinxu humanrhinovirusesprevailedamongchildreninthesettingofwearingfacemasksinshanghai2020 |