The Molecular Evolutionary Patterns of the Insulin/FOXO Signaling Pathway
The insulin/insulin growth factor-1 (IGF1)/FOXO (IIF) signal transduction pathway plays a core role in the endocrine system. Although the components of this pathway have been well characterized, the evolutionary pattern remains poorly understood. Here, we perform a comprehensive analysis to study wh...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2013-01-01
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| Series: | Evolutionary Bioinformatics |
| Online Access: | https://doi.org/10.4137/EBO.S10539 |
| _version_ | 1828822299144355840 |
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| author | Minghui Wang Qishan Wang Zhen Wang Qingping Wang Xiangzhe Zhang Yuchun Pan |
| author_facet | Minghui Wang Qishan Wang Zhen Wang Qingping Wang Xiangzhe Zhang Yuchun Pan |
| author_sort | Minghui Wang |
| collection | DOAJ |
| description | The insulin/insulin growth factor-1 (IGF1)/FOXO (IIF) signal transduction pathway plays a core role in the endocrine system. Although the components of this pathway have been well characterized, the evolutionary pattern remains poorly understood. Here, we perform a comprehensive analysis to study whether the differences of signaling transduction elements exist as well as to determine whether the genes are subject to equivalent evolutionary forces and how natural selection shapes the evolution pattern of proteins in an interacting system. Our results demonstrate that most IIF pathway components are present throughout all animal phyla investigated here, and they are under strong selective constraint. Remarkably, we detect that the components in the middle of the pathway undergo stronger purifying selection, which is different from previous similar reports. We also find that the d N /d S may be influenced by quite complicated factors including codon bias, protein length among others. |
| first_indexed | 2024-12-12T13:11:16Z |
| format | Article |
| id | doaj.art-cfe2f0634d7848f998cf1572747f3278 |
| institution | Directory Open Access Journal |
| issn | 1176-9343 |
| language | English |
| last_indexed | 2024-12-12T13:11:16Z |
| publishDate | 2013-01-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Evolutionary Bioinformatics |
| spelling | doaj.art-cfe2f0634d7848f998cf1572747f32782022-12-22T00:23:31ZengSAGE PublishingEvolutionary Bioinformatics1176-93432013-01-01910.4137/EBO.S10539The Molecular Evolutionary Patterns of the Insulin/FOXO Signaling PathwayMinghui Wang0Qishan Wang1Zhen Wang2Qingping Wang3Xiangzhe Zhang4Yuchun Pan5Shanghai Key Laboratory of Veterinary Biotechnology, Shanghai, China.Shanghai Key Laboratory of Veterinary Biotechnology, Shanghai, China.School of Agriculture and Biology, Department of Animal Sciences, Shanghai Jiao Tong University, Shanghai, PR China.School of Agriculture and Biology, Department of Animal Sciences, Shanghai Jiao Tong University, Shanghai, PR China.School of Agriculture and Biology, Department of Animal Sciences, Shanghai Jiao Tong University, Shanghai, PR China.Shanghai Key Laboratory of Veterinary Biotechnology, Shanghai, China.The insulin/insulin growth factor-1 (IGF1)/FOXO (IIF) signal transduction pathway plays a core role in the endocrine system. Although the components of this pathway have been well characterized, the evolutionary pattern remains poorly understood. Here, we perform a comprehensive analysis to study whether the differences of signaling transduction elements exist as well as to determine whether the genes are subject to equivalent evolutionary forces and how natural selection shapes the evolution pattern of proteins in an interacting system. Our results demonstrate that most IIF pathway components are present throughout all animal phyla investigated here, and they are under strong selective constraint. Remarkably, we detect that the components in the middle of the pathway undergo stronger purifying selection, which is different from previous similar reports. We also find that the d N /d S may be influenced by quite complicated factors including codon bias, protein length among others.https://doi.org/10.4137/EBO.S10539 |
| spellingShingle | Minghui Wang Qishan Wang Zhen Wang Qingping Wang Xiangzhe Zhang Yuchun Pan The Molecular Evolutionary Patterns of the Insulin/FOXO Signaling Pathway Evolutionary Bioinformatics |
| title | The Molecular Evolutionary Patterns of the Insulin/FOXO Signaling Pathway |
| title_full | The Molecular Evolutionary Patterns of the Insulin/FOXO Signaling Pathway |
| title_fullStr | The Molecular Evolutionary Patterns of the Insulin/FOXO Signaling Pathway |
| title_full_unstemmed | The Molecular Evolutionary Patterns of the Insulin/FOXO Signaling Pathway |
| title_short | The Molecular Evolutionary Patterns of the Insulin/FOXO Signaling Pathway |
| title_sort | molecular evolutionary patterns of the insulin foxo signaling pathway |
| url | https://doi.org/10.4137/EBO.S10539 |
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