Comparative evaluation of darbepoetin therapy in non-regenerative anaemia associated with Babesia gibsoni infection in dogs
The present study describes a comparative evaluation of haemato-therapeutic response to darbepoetin therapy in non-regenerative anaemia associated with Babesia gibsoni infection in dogs. A total of 68 dogs, presented at Teaching Veterinary Clinical Complex, Mannuthy with signs of anaemia, weaknes...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Director of Academics and Research, Kerala Veterinary and Animal Sciences University
2022-12-01
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| Series: | Journal of Veterinary and Animal Sciences |
| Subjects: | |
| Online Access: | https://jvas.in/public_html/upload/article_file/article_file_ro1v6b.pdf?t=ro1v6b |
| Summary: | The present study describes a comparative evaluation of haemato-therapeutic response
to darbepoetin therapy in non-regenerative anaemia associated with Babesia gibsoni infection
in dogs. A total of 68 dogs, presented at Teaching Veterinary Clinical Complex, Mannuthy with
signs of anaemia, weakness, anorexia and pallor of mucous membranes were screened for nonregenerative
anaemia. Twenty dogs with a reticulocyte count of < 60,000/μL, haematocrit of < 30
per cent and positive for B. gibsoni were selected for detailed study. The twenty dogs were divided
into two groups of ten animals and were subjected to estimation of complete blood count and
analysis of serum protein and iron status. Ten dogs brought to the hospital for vaccination or health
check-up served as healthy control. Haematological examination revealed significant anaemia
and thrombocytopenia in both the groups. Serum total protein, albumin and total iron binding
capacity revealed no difference between diseased groups with the healthy control. Serum iron and
percentage transferrin saturation were similar in Group I and II, but significantly higher than healthy
control. To compare darbepoetin efficacy, Group I dogs were administered with clindamycin and
doxycycline for three weeks, whereas Group II was given with darbepoetin at the dose rate of 0.5
μg/kg body weight at weekly intervals for three weeks in addition to clindamycin-doxycycline as in
Group I. Dogs of both groups showed complete remission of clinical signs within 10 days of therapy.
Statistical analysis revealed no significant difference in haematological parameters between
the treatment groups. It can be concluded from this study that there is no added advantage of
darbepoetin therapy over conventional therapies against non-regenerative anaemia associated
with B. gibsoni infection in dogs. |
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| ISSN: | 0971-0701 2582-0605 |