Hypotensive, vasorelaxant and antihypertensive activities of the hexane extract of Anacardium occidentale Linn
Anacardium occidentale is widely used in folk medicine in Brazil, India, and Africa to treat inflammation, diabetes and hypertension. The aim of the study was to assess the hypotensive, vasorelaxant and antihypertensive effects produced by the hexane extract from the leaves of A. occidentale (HEAO)...
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| Format: | Article |
| Language: | English |
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University of Belgrade, University of Novi Sad
2018-01-01
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| Series: | Archives of Biological Sciences |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-4664/2018/0354-46641800006C.pdf |
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| author | da Costa Cintia D.F. Herculano Edla A. Silva Jessyka C.G. Paulino Emanuel T. Bernardino Alessandro C. Araújo-Júnior João X. Sant’ana Antônio Euzébio G. Salvador Marcos J. Ribeiro Êurica A.N. |
| author_facet | da Costa Cintia D.F. Herculano Edla A. Silva Jessyka C.G. Paulino Emanuel T. Bernardino Alessandro C. Araújo-Júnior João X. Sant’ana Antônio Euzébio G. Salvador Marcos J. Ribeiro Êurica A.N. |
| author_sort | da Costa Cintia D.F. |
| collection | DOAJ |
| description | Anacardium occidentale is widely used in folk medicine in Brazil, India, and Africa to treat inflammation, diabetes and hypertension. The aim of the study was to assess the hypotensive, vasorelaxant and antihypertensive effects produced by the hexane extract from the leaves of A. occidentale (HEAO) in rats. The animals were anesthetized, and polyethylene catheters were embedded into the lower abdominal aorta and the inferior vena cava for blood pressure measurements and drug administration. The HEAO was injected and the mean arterial pressure and heart rate were measured. The effects of the HEAO on isolated rat mesenteric rings with and without endothelium were investigated. HEAO induced hypotension and bradycardia in normotensive rats. After pretreatment with L-NAME, indomethacin, atropine or hexamethonium, these effects were attenuated. In mesenteric rings, HEAO antagonized the contractile effects induced by phenylephrine or KCl. This effect was inhibited after removal of the vascular endothelium. Oral administration of the HEAO decreased significant mean arterial pressure in spontaneously hypertensive rats. Mass spectrometric analysis of HEAO identified malic acid and quercetin. Our findings demonstrate that HEAO produces hypotension probably due to a reduction in peripheral vascular resistance, mediated by the endothelium, in part, by a decrease in cardiac output. Bradycardia appears to be due to the indirect activation of cardiac muscarinic receptors via activation of the vagus nerve. The HEAO also induces an antihypertensive effect. |
| first_indexed | 2024-12-10T10:41:19Z |
| format | Article |
| id | doaj.art-cfe3f3a3307442b396f1f0cebd567c38 |
| institution | Directory Open Access Journal |
| issn | 0354-4664 1821-4339 |
| language | English |
| last_indexed | 2024-12-10T10:41:19Z |
| publishDate | 2018-01-01 |
| publisher | University of Belgrade, University of Novi Sad |
| record_format | Article |
| series | Archives of Biological Sciences |
| spelling | doaj.art-cfe3f3a3307442b396f1f0cebd567c382022-12-22T01:52:19ZengUniversity of Belgrade, University of Novi SadArchives of Biological Sciences0354-46641821-43392018-01-0170345946810.2298/ABS171109006C0354-46641800006CHypotensive, vasorelaxant and antihypertensive activities of the hexane extract of Anacardium occidentale Linnda Costa Cintia D.F.0Herculano Edla A.1Silva Jessyka C.G.2Paulino Emanuel T.3Bernardino Alessandro C.4Araújo-Júnior João X.5Sant’ana Antônio Euzébio G.6Salvador Marcos J.7Ribeiro Êurica A.N.8Federal University of Alagoas, School of Nursing and Pharmacy, Laboratory of Cardiovascular Pharmacology, Campus A. C. Simões, Maceió, Alagoas, BrazilFederal University of Alagoas, School of Nursing and Pharmacy, Laboratory of Cardiovascular Pharmacology, Campus A. C. Simões, Maceió, Alagoas, BrazilFederal University of Alagoas, School of Nursing and Pharmacy, Laboratory of Cardiovascular Pharmacology, Campus A. C. Simões, Maceió, Alagoas, BrazilFederal University of Alagoas, School of Nursing and Pharmacy, Laboratory of Cardiovascular Pharmacology, Campus A. C. Simões, Maceió, Alagoas, BrazilFederal University of Alagoas, School of Nursing and Pharmacy, Laboratory of Cardiovascular Pharmacology, Campus A. C. Simões, Maceió, Alagoas, BrazilFederal University of Alagoas, School of Nursing and Pharmacy, Laboratory of Cardiovascular Pharmacology, Campus A. C. Simões, Maceió, Alagoas, Brazil + Federal University of Alagoas, Institute of Chemistry and Biotechnology, Campus A. C. Simões, Maceió, Federal University of Alagoas, Institute of Chemistry and Biotechnology, Campus A. C. Simões, Maceió, Alagoas, BrazilState University of Campinas, College of Pharmacy, Department of Plant Biology, Institute of Biology, Campinas-São Paulo, BrazilFederal University of Alagoas, School of Nursing and Pharmacy, Laboratory of Cardiovascular Pharmacology, Campus A.C. Simões, Maceió, Alagoas, BrazilAnacardium occidentale is widely used in folk medicine in Brazil, India, and Africa to treat inflammation, diabetes and hypertension. The aim of the study was to assess the hypotensive, vasorelaxant and antihypertensive effects produced by the hexane extract from the leaves of A. occidentale (HEAO) in rats. The animals were anesthetized, and polyethylene catheters were embedded into the lower abdominal aorta and the inferior vena cava for blood pressure measurements and drug administration. The HEAO was injected and the mean arterial pressure and heart rate were measured. The effects of the HEAO on isolated rat mesenteric rings with and without endothelium were investigated. HEAO induced hypotension and bradycardia in normotensive rats. After pretreatment with L-NAME, indomethacin, atropine or hexamethonium, these effects were attenuated. In mesenteric rings, HEAO antagonized the contractile effects induced by phenylephrine or KCl. This effect was inhibited after removal of the vascular endothelium. Oral administration of the HEAO decreased significant mean arterial pressure in spontaneously hypertensive rats. Mass spectrometric analysis of HEAO identified malic acid and quercetin. Our findings demonstrate that HEAO produces hypotension probably due to a reduction in peripheral vascular resistance, mediated by the endothelium, in part, by a decrease in cardiac output. Bradycardia appears to be due to the indirect activation of cardiac muscarinic receptors via activation of the vagus nerve. The HEAO also induces an antihypertensive effect.http://www.doiserbia.nb.rs/img/doi/0354-4664/2018/0354-46641800006C.pdfAnacardium occidentaleleavesvasorelaxant activityhypotensionantihypertensive effect |
| spellingShingle | da Costa Cintia D.F. Herculano Edla A. Silva Jessyka C.G. Paulino Emanuel T. Bernardino Alessandro C. Araújo-Júnior João X. Sant’ana Antônio Euzébio G. Salvador Marcos J. Ribeiro Êurica A.N. Hypotensive, vasorelaxant and antihypertensive activities of the hexane extract of Anacardium occidentale Linn Archives of Biological Sciences Anacardium occidentale leaves vasorelaxant activity hypotension antihypertensive effect |
| title | Hypotensive, vasorelaxant and antihypertensive activities of the hexane extract of Anacardium occidentale Linn |
| title_full | Hypotensive, vasorelaxant and antihypertensive activities of the hexane extract of Anacardium occidentale Linn |
| title_fullStr | Hypotensive, vasorelaxant and antihypertensive activities of the hexane extract of Anacardium occidentale Linn |
| title_full_unstemmed | Hypotensive, vasorelaxant and antihypertensive activities of the hexane extract of Anacardium occidentale Linn |
| title_short | Hypotensive, vasorelaxant and antihypertensive activities of the hexane extract of Anacardium occidentale Linn |
| title_sort | hypotensive vasorelaxant and antihypertensive activities of the hexane extract of anacardium occidentale linn |
| topic | Anacardium occidentale leaves vasorelaxant activity hypotension antihypertensive effect |
| url | http://www.doiserbia.nb.rs/img/doi/0354-4664/2018/0354-46641800006C.pdf |
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