Hedgehog inhibitor in the treatment of basal cell skin cancer: case report
Background. In the structure of malignant neoplasms, basal cell skin cancer (BCC) occupies a leading position. In the initial stages of a malignant neoplasm, the main treatments are local treatment methods, both surgical and radiation. However, in about 1.3 % of cases, BCC can become locally or meta...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
ABV-press
2021-04-01
|
| Series: | Опухоли головы и шеи |
| Subjects: | |
| Online Access: | https://ogsh.abvpress.ru/jour/article/view/616 |
| _version_ | 1797876175551332352 |
|---|---|
| author | Sh. I. Musin N. А. Sharafutdinova A. V. Sultanbaev S. V. Osokin B. A. Ibragimov K. V. Menshikov R. T. Ayupov |
| author_facet | Sh. I. Musin N. А. Sharafutdinova A. V. Sultanbaev S. V. Osokin B. A. Ibragimov K. V. Menshikov R. T. Ayupov |
| author_sort | Sh. I. Musin |
| collection | DOAJ |
| description | Background. In the structure of malignant neoplasms, basal cell skin cancer (BCC) occupies a leading position. In the initial stages of a malignant neoplasm, the main treatments are local treatment methods, both surgical and radiation. However, in about 1.3 % of cases, BCC can become locally or metastatic in which local treatment methods are limited. With the development of targeted drugs, such as the Hedgehog pathway inhibitor, the possibilities for effective and safe treatment of this category of patients have appeared.The objective is to present the clinical case of treating a patient with BCC who is receiving systemic therapy with a Hedgehog signaling pathway inhibitor.Case report. According to the patient, a tumor in the lower eyelid of the left eye appeared in 2000, did not seek medical help. In 2011, he applied to the clinic and was diagnosed with skin cancer of the lower eyelid of the left eye T2bN0M0. The patient refused the proposed treatment. Reapplied only in June 2017 already with a locally distributed process. The case is recognized as unresectable. From June 30, 2017 to September 4, 2017, he underwent a course of a radical program of radiotherapy, with a positive effect. 07/01/2019, he relapsed with a relapse of an orbital tumor on the left. From July 16, 2019, the patient began taking the drug wismodegib 150 mg once a day. Against the background of the treatment, control CT studies on 11/24/2019 and 11/03/2020 compared with CT data from 07/09/2019 reduced the volume of the tumor by 78 and 82 %. The patient currently continues to take wismodegib.Conclusion. The clinical case demonstrates successful treatment of locally advanced basal cell skin cancer with a Hedgehog signaling pathway inhibitor. |
| first_indexed | 2024-04-10T01:59:04Z |
| format | Article |
| id | doaj.art-cfe738c4ca0e4b659538fb885ede91ba |
| institution | Directory Open Access Journal |
| issn | 2222-1468 2411-4634 |
| language | Russian |
| last_indexed | 2024-04-10T01:59:04Z |
| publishDate | 2021-04-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли головы и шеи |
| spelling | doaj.art-cfe738c4ca0e4b659538fb885ede91ba2023-03-13T08:43:21ZrusABV-pressОпухоли головы и шеи2222-14682411-46342021-04-0111110911410.17650/2222-1468-2021-11-1-109-114435Hedgehog inhibitor in the treatment of basal cell skin cancer: case reportSh. I. Musin0N. А. Sharafutdinova1A. V. Sultanbaev2S. V. Osokin3B. A. Ibragimov4K. V. Menshikov5R. T. Ayupov6ГАУЗ Республиканский клинический онкологический диспансер Минздрава Республики Башкортостан; ФГБОУ ВО Башкирский государственный медицинский университет» Минздрава РоссииГАУЗ Республиканский клинический онкологический диспансер Минздрава Республики БашкортостанГАУЗ Республиканский клинический онкологический диспансер Минздрава Республики БашкортостанГАУЗ Республиканский клинический онкологический диспансер Минздрава Республики Башкортостан; ФГБОУ ВО Башкирский государственный медицинский университет» Минздрава РоссииГАУЗ Республиканский клинический онкологический диспансер Минздрава Республики БашкортостанГАУЗ Республиканский клинический онкологический диспансер Минздрава Республики Башкортостан; ФГБОУ ВО Башкирский государственный медицинский университет» Минздрава РоссииГАУЗ Республиканский клинический онкологический диспансер Минздрава Республики БашкортостанBackground. In the structure of malignant neoplasms, basal cell skin cancer (BCC) occupies a leading position. In the initial stages of a malignant neoplasm, the main treatments are local treatment methods, both surgical and radiation. However, in about 1.3 % of cases, BCC can become locally or metastatic in which local treatment methods are limited. With the development of targeted drugs, such as the Hedgehog pathway inhibitor, the possibilities for effective and safe treatment of this category of patients have appeared.The objective is to present the clinical case of treating a patient with BCC who is receiving systemic therapy with a Hedgehog signaling pathway inhibitor.Case report. According to the patient, a tumor in the lower eyelid of the left eye appeared in 2000, did not seek medical help. In 2011, he applied to the clinic and was diagnosed with skin cancer of the lower eyelid of the left eye T2bN0M0. The patient refused the proposed treatment. Reapplied only in June 2017 already with a locally distributed process. The case is recognized as unresectable. From June 30, 2017 to September 4, 2017, he underwent a course of a radical program of radiotherapy, with a positive effect. 07/01/2019, he relapsed with a relapse of an orbital tumor on the left. From July 16, 2019, the patient began taking the drug wismodegib 150 mg once a day. Against the background of the treatment, control CT studies on 11/24/2019 and 11/03/2020 compared with CT data from 07/09/2019 reduced the volume of the tumor by 78 and 82 %. The patient currently continues to take wismodegib.Conclusion. The clinical case demonstrates successful treatment of locally advanced basal cell skin cancer with a Hedgehog signaling pathway inhibitor.https://ogsh.abvpress.ru/jour/article/view/616базальноклеточный рак кожиместно-распространенный рак кожиингибитор сигнального пути hedgehog |
| spellingShingle | Sh. I. Musin N. А. Sharafutdinova A. V. Sultanbaev S. V. Osokin B. A. Ibragimov K. V. Menshikov R. T. Ayupov Hedgehog inhibitor in the treatment of basal cell skin cancer: case report Опухоли головы и шеи базальноклеточный рак кожи местно-распространенный рак кожи ингибитор сигнального пути hedgehog |
| title | Hedgehog inhibitor in the treatment of basal cell skin cancer: case report |
| title_full | Hedgehog inhibitor in the treatment of basal cell skin cancer: case report |
| title_fullStr | Hedgehog inhibitor in the treatment of basal cell skin cancer: case report |
| title_full_unstemmed | Hedgehog inhibitor in the treatment of basal cell skin cancer: case report |
| title_short | Hedgehog inhibitor in the treatment of basal cell skin cancer: case report |
| title_sort | hedgehog inhibitor in the treatment of basal cell skin cancer case report |
| topic | базальноклеточный рак кожи местно-распространенный рак кожи ингибитор сигнального пути hedgehog |
| url | https://ogsh.abvpress.ru/jour/article/view/616 |
| work_keys_str_mv | AT shimusin hedgehoginhibitorinthetreatmentofbasalcellskincancercasereport AT nasharafutdinova hedgehoginhibitorinthetreatmentofbasalcellskincancercasereport AT avsultanbaev hedgehoginhibitorinthetreatmentofbasalcellskincancercasereport AT svosokin hedgehoginhibitorinthetreatmentofbasalcellskincancercasereport AT baibragimov hedgehoginhibitorinthetreatmentofbasalcellskincancercasereport AT kvmenshikov hedgehoginhibitorinthetreatmentofbasalcellskincancercasereport AT rtayupov hedgehoginhibitorinthetreatmentofbasalcellskincancercasereport |