Prognostic Value of the Neutrophil-to-Lymphocyte Ratio in Patients with Chronic Internal Carotid Artery Occlusion Complicated by Cerebral Infarction
Zhuoyin Qiu,1,2,* Tingting Guo,1,2,* Xihua Sheng,1,2 Ying Tang,1,2 Huaping Du1,2 1Department of Neurology, Suzhou Ninth People’s Hospital, Suzhou, People’s Republic of China; 2Department of Neurology, Suzhou Ninth Hospital Affiliated to Soochow University, Suzhou, People’s Republic o...
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| Format: | Article |
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Dove Medical Press
2022-10-01
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| Series: | Neuropsychiatric Disease and Treatment |
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| Online Access: | https://www.dovepress.com/prognostic-value-of-the-neutrophil-to-lymphocyte-ratio-in-patients-wit-peer-reviewed-fulltext-article-NDT |
| _version_ | 1811182697110831104 |
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| author | Qiu Z Guo T Sheng X Tang Y Du H |
| author_facet | Qiu Z Guo T Sheng X Tang Y Du H |
| author_sort | Qiu Z |
| collection | DOAJ |
| description | Zhuoyin Qiu,1,2,* Tingting Guo,1,2,* Xihua Sheng,1,2 Ying Tang,1,2 Huaping Du1,2 1Department of Neurology, Suzhou Ninth People’s Hospital, Suzhou, People’s Republic of China; 2Department of Neurology, Suzhou Ninth Hospital Affiliated to Soochow University, Suzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Huaping Du, Department of Neurology, Suzhou Ninth People’s Hospital, No. 2666, Ludang Road, Wujiang District, Suzhou, Jiangsu, 215000, People’s Republic of China, Tel +86 512-82885052, Email duhuaping226@126.comPurpose: This study aims to investigate the prognostic value of the peripheral neutrophil-to-lymphocyte ratio (NLR) in patients with chronic internal carotid artery occlusion (CICAO) complicated by cerebral infarction.Patients and Methods: The clinical data of 99 CICAO patients complicated by cerebral infarction were retrospectively analyzed. The modified Rankin Scale (mRS) was used to assess their 3-month prognosis, and a multivariate logistic regression model was established to explore risk factors for poor prognosis.Results: Multivariate logistic regression analysis demonstrated that NLR (OR=2.114; 95% CI: 1.129– 3.959) and baseline National Institute of Health Stroke Scale (NIHSS; OR=1.288, 95% CI: 1.053– 1.574) score were risk factors of poor prognosis. The area under the receiver operator characteristic (ROC) curve of NLR in predicting the 3-month outcome after onset was 0.717 (95% CI: 0.606– 0.828, P< 0.000). The optimal cut-off value was 3.22, with a sensitivity of 0.743 and a specificity of 0.791.Conclusion: NLR is an independent risk factor for the poor prognosis of CICAO patients complicated by cerebral infarction and can serve as an indicator for clinical prognosis.Keywords: chronic internal carotid artery occlusion, cerebral infarction, neutrophil-to-lymphocyte ratio, prognosis, predictive factors |
| first_indexed | 2024-04-11T09:36:04Z |
| format | Article |
| id | doaj.art-cfe7c88294c3426b8dfc5a14275b635f |
| institution | Directory Open Access Journal |
| issn | 1178-2021 |
| language | English |
| last_indexed | 2024-04-11T09:36:04Z |
| publishDate | 2022-10-01 |
| publisher | Dove Medical Press |
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| series | Neuropsychiatric Disease and Treatment |
| spelling | doaj.art-cfe7c88294c3426b8dfc5a14275b635f2022-12-22T04:31:43ZengDove Medical PressNeuropsychiatric Disease and Treatment1178-20212022-10-01Volume 182265227178962Prognostic Value of the Neutrophil-to-Lymphocyte Ratio in Patients with Chronic Internal Carotid Artery Occlusion Complicated by Cerebral InfarctionQiu ZGuo TSheng XTang YDu HZhuoyin Qiu,1,2,* Tingting Guo,1,2,* Xihua Sheng,1,2 Ying Tang,1,2 Huaping Du1,2 1Department of Neurology, Suzhou Ninth People’s Hospital, Suzhou, People’s Republic of China; 2Department of Neurology, Suzhou Ninth Hospital Affiliated to Soochow University, Suzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Huaping Du, Department of Neurology, Suzhou Ninth People’s Hospital, No. 2666, Ludang Road, Wujiang District, Suzhou, Jiangsu, 215000, People’s Republic of China, Tel +86 512-82885052, Email duhuaping226@126.comPurpose: This study aims to investigate the prognostic value of the peripheral neutrophil-to-lymphocyte ratio (NLR) in patients with chronic internal carotid artery occlusion (CICAO) complicated by cerebral infarction.Patients and Methods: The clinical data of 99 CICAO patients complicated by cerebral infarction were retrospectively analyzed. The modified Rankin Scale (mRS) was used to assess their 3-month prognosis, and a multivariate logistic regression model was established to explore risk factors for poor prognosis.Results: Multivariate logistic regression analysis demonstrated that NLR (OR=2.114; 95% CI: 1.129– 3.959) and baseline National Institute of Health Stroke Scale (NIHSS; OR=1.288, 95% CI: 1.053– 1.574) score were risk factors of poor prognosis. The area under the receiver operator characteristic (ROC) curve of NLR in predicting the 3-month outcome after onset was 0.717 (95% CI: 0.606– 0.828, P< 0.000). The optimal cut-off value was 3.22, with a sensitivity of 0.743 and a specificity of 0.791.Conclusion: NLR is an independent risk factor for the poor prognosis of CICAO patients complicated by cerebral infarction and can serve as an indicator for clinical prognosis.Keywords: chronic internal carotid artery occlusion, cerebral infarction, neutrophil-to-lymphocyte ratio, prognosis, predictive factorshttps://www.dovepress.com/prognostic-value-of-the-neutrophil-to-lymphocyte-ratio-in-patients-wit-peer-reviewed-fulltext-article-NDTchronic internal carotid artery occlusioncerebral infarctionneutrophil-to-lymphocyte ratioprognosispredictive factors |
| spellingShingle | Qiu Z Guo T Sheng X Tang Y Du H Prognostic Value of the Neutrophil-to-Lymphocyte Ratio in Patients with Chronic Internal Carotid Artery Occlusion Complicated by Cerebral Infarction Neuropsychiatric Disease and Treatment chronic internal carotid artery occlusion cerebral infarction neutrophil-to-lymphocyte ratio prognosis predictive factors |
| title | Prognostic Value of the Neutrophil-to-Lymphocyte Ratio in Patients with Chronic Internal Carotid Artery Occlusion Complicated by Cerebral Infarction |
| title_full | Prognostic Value of the Neutrophil-to-Lymphocyte Ratio in Patients with Chronic Internal Carotid Artery Occlusion Complicated by Cerebral Infarction |
| title_fullStr | Prognostic Value of the Neutrophil-to-Lymphocyte Ratio in Patients with Chronic Internal Carotid Artery Occlusion Complicated by Cerebral Infarction |
| title_full_unstemmed | Prognostic Value of the Neutrophil-to-Lymphocyte Ratio in Patients with Chronic Internal Carotid Artery Occlusion Complicated by Cerebral Infarction |
| title_short | Prognostic Value of the Neutrophil-to-Lymphocyte Ratio in Patients with Chronic Internal Carotid Artery Occlusion Complicated by Cerebral Infarction |
| title_sort | prognostic value of the neutrophil to lymphocyte ratio in patients with chronic internal carotid artery occlusion complicated by cerebral infarction |
| topic | chronic internal carotid artery occlusion cerebral infarction neutrophil-to-lymphocyte ratio prognosis predictive factors |
| url | https://www.dovepress.com/prognostic-value-of-the-neutrophil-to-lymphocyte-ratio-in-patients-wit-peer-reviewed-fulltext-article-NDT |
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