Hypouricemia and nephroprotection of Coix lacryma-jobi L. seed extract
The Coix lacryma-jobi L. or Adlay seed has been used as a healthy food and herb in many Asian countries. A previous in vitro study found that it has an inhibitory effect on xanthine oxidase (XOD) activity but its use as a traditional medicine in the treatment of hyperuricemia and gout has a lacked...
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| Format: | Article |
| Language: | English |
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Prince of Songkla University
2015-08-01
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| Series: | Songklanakarin Journal of Science and Technology (SJST) |
| Subjects: | |
| Online Access: | http://rdo.psu.ac.th/sjstweb/journal/37-4/37-4-9.pdf |
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| author | Ormjai Taejarernwiriyakul Naohiko Anzai Promsuk Jutabha Wantika Kruanamkam Suparat Chanluang |
| author_facet | Ormjai Taejarernwiriyakul Naohiko Anzai Promsuk Jutabha Wantika Kruanamkam Suparat Chanluang |
| author_sort | Ormjai Taejarernwiriyakul |
| collection | DOAJ |
| description | The Coix lacryma-jobi L. or Adlay seed has been used as a healthy food and herb in many Asian countries. A previous
in vitro study found that it has an inhibitory effect on xanthine oxidase (XOD) activity but its use as a traditional medicine
in the treatment of hyperuricemia and gout has a lacked scientific evidence. This study aimed to investigate the effects of
Adlay seed extract on the level of plasma uric acid (Pua), reduction in fractional excretion of urate (%FEua), decreasing
creatinine clearance (Ccr), and increasing plasma creatinine and urea nitrogen in hyperuricemic mice. The steps of the study
comprised collecting and inducing the sample mice by giving potassium oxonate and uric acid and treating the hyperuricemic
mice by giving Adlay seed extract at doses of 0.1 to 100 mg/kg for 10 days. The results showed that Adlay seed extract
significantly reduced Pua in a dose-dependent manner, increased %FEua and Ccr to normal level at doses of 10 and 100
mg/kg and also inhibited XOD activity in liver and plasma in hyperuricemic mice. From this results indicated that Adlay seed
extract has hypouricemia and nephroprotective action in hyperuricemic mice. |
| first_indexed | 2024-04-12T00:18:25Z |
| format | Article |
| id | doaj.art-cfe84b64688b4d81b1c390c652fbd213 |
| institution | Directory Open Access Journal |
| issn | 0125-3395 |
| language | English |
| last_indexed | 2024-04-12T00:18:25Z |
| publishDate | 2015-08-01 |
| publisher | Prince of Songkla University |
| record_format | Article |
| series | Songklanakarin Journal of Science and Technology (SJST) |
| spelling | doaj.art-cfe84b64688b4d81b1c390c652fbd2132022-12-22T03:55:47ZengPrince of Songkla UniversitySongklanakarin Journal of Science and Technology (SJST)0125-33952015-08-01374441447Hypouricemia and nephroprotection of Coix lacryma-jobi L. seed extractOrmjai Taejarernwiriyakul0Naohiko Anzai1Promsuk Jutabha2Wantika Kruanamkam3Suparat Chanluang4Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Warin Chamrap, Ubon Ratchathani, Thailand.Dokkyo Medical University, School of Medicine, Tochigi, Japan.Dokkyo Medical University, School of Medicine, Tochigi, Japan.Faculty of Science, Rangsit University, Mueang, Pathum Thani, Thailand.Faculty of Pharmaceutical Sciences, Ubon Ratchathani University, Warin Chamrap, Ubon Ratchathani, Thailand.The Coix lacryma-jobi L. or Adlay seed has been used as a healthy food and herb in many Asian countries. A previous in vitro study found that it has an inhibitory effect on xanthine oxidase (XOD) activity but its use as a traditional medicine in the treatment of hyperuricemia and gout has a lacked scientific evidence. This study aimed to investigate the effects of Adlay seed extract on the level of plasma uric acid (Pua), reduction in fractional excretion of urate (%FEua), decreasing creatinine clearance (Ccr), and increasing plasma creatinine and urea nitrogen in hyperuricemic mice. The steps of the study comprised collecting and inducing the sample mice by giving potassium oxonate and uric acid and treating the hyperuricemic mice by giving Adlay seed extract at doses of 0.1 to 100 mg/kg for 10 days. The results showed that Adlay seed extract significantly reduced Pua in a dose-dependent manner, increased %FEua and Ccr to normal level at doses of 10 and 100 mg/kg and also inhibited XOD activity in liver and plasma in hyperuricemic mice. From this results indicated that Adlay seed extract has hypouricemia and nephroprotective action in hyperuricemic mice.http://rdo.psu.ac.th/sjstweb/journal/37-4/37-4-9.pdfCoix lacryma-jobi Lhypouricemianephroprotectionxanthine oxidasepotassium oxonate |
| spellingShingle | Ormjai Taejarernwiriyakul Naohiko Anzai Promsuk Jutabha Wantika Kruanamkam Suparat Chanluang Hypouricemia and nephroprotection of Coix lacryma-jobi L. seed extract Songklanakarin Journal of Science and Technology (SJST) Coix lacryma-jobi L hypouricemia nephroprotection xanthine oxidase potassium oxonate |
| title | Hypouricemia and nephroprotection of Coix lacryma-jobi L. seed extract |
| title_full | Hypouricemia and nephroprotection of Coix lacryma-jobi L. seed extract |
| title_fullStr | Hypouricemia and nephroprotection of Coix lacryma-jobi L. seed extract |
| title_full_unstemmed | Hypouricemia and nephroprotection of Coix lacryma-jobi L. seed extract |
| title_short | Hypouricemia and nephroprotection of Coix lacryma-jobi L. seed extract |
| title_sort | hypouricemia and nephroprotection of coix lacryma jobi l seed extract |
| topic | Coix lacryma-jobi L hypouricemia nephroprotection xanthine oxidase potassium oxonate |
| url | http://rdo.psu.ac.th/sjstweb/journal/37-4/37-4-9.pdf |
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