The role of post-transcriptional regulation in SARS-CoV-2 infection and pathogenicity
The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus has had a significant impact on global social and economic stability. To combat this, researchers have turned to omics approaches, particularly epitranscriptomics, to limit infection and develop ef...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1256574/full |
| _version_ | 1797614241555939328 |
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| author | Xuan Wang Zecheng Chang Tingting Zhao Weiyao Zhong Jingwei Shi Guoqing Wang Xuesong Xu |
| author_facet | Xuan Wang Zecheng Chang Tingting Zhao Weiyao Zhong Jingwei Shi Guoqing Wang Xuesong Xu |
| author_sort | Xuan Wang |
| collection | DOAJ |
| description | The COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus has had a significant impact on global social and economic stability. To combat this, researchers have turned to omics approaches, particularly epitranscriptomics, to limit infection and develop effective therapeutic strategies. Multi-omics can provide the host response dynamics during multiple disease phases to reveal the molecular and cellular landscapes. Epitranscriptomics focuses on the mechanisms of gene transcription in cells and tissues and the relationship between genetic material and epigenetic regulation. This review highlights the role of post-transcriptional regulation in SARS-CoV-2, which affect various processes such as virus infection, replication, immunogenicity, and pathogenicity. The review also explains the formation mechanism of post-transcriptional modifications and how they can be regulated to combat viral infection and pathogenicity. |
| first_indexed | 2024-03-11T07:06:57Z |
| format | Article |
| id | doaj.art-cfe8533a62db44a7baa430c2e6b34c6e |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-11T07:06:57Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-cfe8533a62db44a7baa430c2e6b34c6e2023-11-17T08:55:52ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-11-011410.3389/fimmu.2023.12565741256574The role of post-transcriptional regulation in SARS-CoV-2 infection and pathogenicityXuan WangZecheng ChangTingting ZhaoWeiyao ZhongJingwei ShiGuoqing WangXuesong XuThe COVID-19 pandemic caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) virus has had a significant impact on global social and economic stability. To combat this, researchers have turned to omics approaches, particularly epitranscriptomics, to limit infection and develop effective therapeutic strategies. Multi-omics can provide the host response dynamics during multiple disease phases to reveal the molecular and cellular landscapes. Epitranscriptomics focuses on the mechanisms of gene transcription in cells and tissues and the relationship between genetic material and epigenetic regulation. This review highlights the role of post-transcriptional regulation in SARS-CoV-2, which affect various processes such as virus infection, replication, immunogenicity, and pathogenicity. The review also explains the formation mechanism of post-transcriptional modifications and how they can be regulated to combat viral infection and pathogenicity.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1256574/fullpost-transcriptional modificationSARS-CoV-2pathogenicityvirus-host interactionregulation |
| spellingShingle | Xuan Wang Zecheng Chang Tingting Zhao Weiyao Zhong Jingwei Shi Guoqing Wang Xuesong Xu The role of post-transcriptional regulation in SARS-CoV-2 infection and pathogenicity Frontiers in Immunology post-transcriptional modification SARS-CoV-2 pathogenicity virus-host interaction regulation |
| title | The role of post-transcriptional regulation in SARS-CoV-2 infection and pathogenicity |
| title_full | The role of post-transcriptional regulation in SARS-CoV-2 infection and pathogenicity |
| title_fullStr | The role of post-transcriptional regulation in SARS-CoV-2 infection and pathogenicity |
| title_full_unstemmed | The role of post-transcriptional regulation in SARS-CoV-2 infection and pathogenicity |
| title_short | The role of post-transcriptional regulation in SARS-CoV-2 infection and pathogenicity |
| title_sort | role of post transcriptional regulation in sars cov 2 infection and pathogenicity |
| topic | post-transcriptional modification SARS-CoV-2 pathogenicity virus-host interaction regulation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1256574/full |
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