Glucose 6-phosphate dehydrogenase 6-phosphogluconolactonase: characterization of the Plasmodium vivax enzyme and inhibitor studies

Glucose 6-phosphate dehydrogenase 6-phosphogluconolactonase: characterization of the Plasmodium vivax enzyme and inhibitor studies

Abstract Background Since malaria parasites highly depend on ribose 5-phosphate for DNA and RNA synthesis and on NADPH as a source of reducing equivalents, the pentose phosphate pathway (PPP) is considered an excellent anti-malarial drug target. In Plasmodium, a bifunctional enzyme named glucose 6-p...

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Bibliographic Details
Main Authors: Kristina Haeussler, Isabell Berneburg, Esther Jortzik, Julia Hahn, Mahsa Rahbari, Norma Schulz, Janina Preuss, Viktor A. Zapol’skii, Lars Bode, Anthony B. Pinkerton, Dieter E. Kaufmann, Stefan Rahlfs, Katja Becker
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Malaria Journal
Subjects:
Glucose 6-phosphate dehydrogenase
Inhibitors
Plasmodium vivax
Plasmodium falciparum
SNP
Malaria
Online Access:http://link.springer.com/article/10.1186/s12936-019-2651-z

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