Transcellular Transport of Heparin-coated Magnetic Iron Oxide Nanoparticles (Hep-MION) Under the Influence of an Applied Magnetic Field
In this study, magnetic iron oxide nanoparticles coated with heparin (Hep-MION) were synthesized and the transcellular transport of the nanoparticles across epithelial cell monolayers on porous polyester membranes was investigated. An externally applied magnetic field facilitated the transport of th...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2010-04-01
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| Series: | Pharmaceutics |
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| Online Access: | http://www.mdpi.com/1999-4923/2/2/119/ |
| _version_ | 1828136328525512704 |
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| author | Kyoung Ah Min Faquan Yu Victor C. Yang Xinyuan Zhang Gus R. Rosania |
| author_facet | Kyoung Ah Min Faquan Yu Victor C. Yang Xinyuan Zhang Gus R. Rosania |
| author_sort | Kyoung Ah Min |
| collection | DOAJ |
| description | In this study, magnetic iron oxide nanoparticles coated with heparin (Hep-MION) were synthesized and the transcellular transport of the nanoparticles across epithelial cell monolayers on porous polyester membranes was investigated. An externally applied magnetic field facilitated the transport of the Hep-MION across cell monolayers. However, high Hep-MION concentrations led to an increased aggregation of nanoparticles on the cell monolayer after application of the magnetic field. Our results indicate that magnetic guidance of Hep-MION most effectively promotes transcellular transport under conditions that minimize formation of magnetically-induced nanoparticle aggregates. Across cell monolayers, the magnet’s attraction led to the greatest increase in mass transport rate in dilute dispersions and in high serum concentrations, suggesting that magnetic guidance may be useful for in vivo targeting of Hep-MION. |
| first_indexed | 2024-04-11T18:02:29Z |
| format | Article |
| id | doaj.art-cfe9ccf7ec164a7bbfcbd7db1218684c |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-04-11T18:02:29Z |
| publishDate | 2010-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-cfe9ccf7ec164a7bbfcbd7db1218684c2022-12-22T04:10:26ZengMDPI AGPharmaceutics1999-49232010-04-012211913510.3390/pharmaceutics2020119Transcellular Transport of Heparin-coated Magnetic Iron Oxide Nanoparticles (Hep-MION) Under the Influence of an Applied Magnetic FieldKyoung Ah MinFaquan YuVictor C. YangXinyuan ZhangGus R. RosaniaIn this study, magnetic iron oxide nanoparticles coated with heparin (Hep-MION) were synthesized and the transcellular transport of the nanoparticles across epithelial cell monolayers on porous polyester membranes was investigated. An externally applied magnetic field facilitated the transport of the Hep-MION across cell monolayers. However, high Hep-MION concentrations led to an increased aggregation of nanoparticles on the cell monolayer after application of the magnetic field. Our results indicate that magnetic guidance of Hep-MION most effectively promotes transcellular transport under conditions that minimize formation of magnetically-induced nanoparticle aggregates. Across cell monolayers, the magnet’s attraction led to the greatest increase in mass transport rate in dilute dispersions and in high serum concentrations, suggesting that magnetic guidance may be useful for in vivo targeting of Hep-MION.http://www.mdpi.com/1999-4923/2/2/119/magnetic iron oxide nanoparticles (MION)magnetic fieldtranscellular transportMDCK cell monolayerdrug targeting |
| spellingShingle | Kyoung Ah Min Faquan Yu Victor C. Yang Xinyuan Zhang Gus R. Rosania Transcellular Transport of Heparin-coated Magnetic Iron Oxide Nanoparticles (Hep-MION) Under the Influence of an Applied Magnetic Field Pharmaceutics magnetic iron oxide nanoparticles (MION) magnetic field transcellular transport MDCK cell monolayer drug targeting |
| title | Transcellular Transport of Heparin-coated Magnetic Iron Oxide Nanoparticles (Hep-MION) Under the Influence of an Applied Magnetic Field |
| title_full | Transcellular Transport of Heparin-coated Magnetic Iron Oxide Nanoparticles (Hep-MION) Under the Influence of an Applied Magnetic Field |
| title_fullStr | Transcellular Transport of Heparin-coated Magnetic Iron Oxide Nanoparticles (Hep-MION) Under the Influence of an Applied Magnetic Field |
| title_full_unstemmed | Transcellular Transport of Heparin-coated Magnetic Iron Oxide Nanoparticles (Hep-MION) Under the Influence of an Applied Magnetic Field |
| title_short | Transcellular Transport of Heparin-coated Magnetic Iron Oxide Nanoparticles (Hep-MION) Under the Influence of an Applied Magnetic Field |
| title_sort | transcellular transport of heparin coated magnetic iron oxide nanoparticles hep mion under the influence of an applied magnetic field |
| topic | magnetic iron oxide nanoparticles (MION) magnetic field transcellular transport MDCK cell monolayer drug targeting |
| url | http://www.mdpi.com/1999-4923/2/2/119/ |
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