Macrophages and dendritic cells density correlates with depth of invasion in the prostate carcinoma
Background: Immune cells interact not only with tumor cells but also with stromal cells facilitating the progression of neoplasia. The ongoing battle between immune cells and the tumor is an important factor influencing the clinical course and outcome of treatment in various types of cancer. The ai...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Scientific Medical Association of Moldova
2020-10-01
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| Series: | The Moldovan Medical Journal |
| Subjects: | |
| Online Access: | http://moldmedjournal.md/wp-content/uploads/2020/09/moldovan-med-j-2020-63-4-globa-et-al-full-text.pdf |
| _version_ | 1818111087700082688 |
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| author | Tatiana Globa Lilian Globa Valeriu David Pavel Globa Elina Pelin Lilian Saptefrati |
| author_facet | Tatiana Globa Lilian Globa Valeriu David Pavel Globa Elina Pelin Lilian Saptefrati |
| author_sort | Tatiana Globa |
| collection | DOAJ |
| description | Background: Immune cells interact not only with tumor cells but also with stromal cells facilitating the progression of neoplasia. The ongoing battle
between immune cells and the tumor is an important factor influencing the clinical course and outcome of treatment in various types of cancer. The aim
of the study was to identify the prognostic value of dendritic cells and macrophages in prostate carcinoma.
Material and methods: This retrospective study analyzed 73 samples of prostate cancer. The macrophages and dendritic cells have been evaluated using
the immunohistochemical methods with CD68 (macrophages) and S100 (dendritic cells). Macrophages were quantified as intratumoral and peritumoral,
and dendritic cells – intraepithelial and stromal. The results were analyzed statistically.
Results: For evaluation of the prognostic impact of immune cells was accomplished a correlation between the total number of CD68+/S100+ cells and
the Gleason score. Thus, statistically significant correlations were obtained both for CD68+ cells (intratumoral p=0.008, peritumoral p=0.001), and for
S100+ cells (intraepithelial p=0.036, stromal p=0.042). In addition, a statistically significant positive linear correlation was observed between the density
of intraepithelial S100+ cells and intratumoral CD68+ cells (p=0.018).
Conclusions: The increase in the density of S100+ and CD68+ cells, as well as the significant association of their density with the histological degree of
the tumor allow us to consider these cells as predictive biomarkers in prostate carcinomas. |
| first_indexed | 2024-12-11T02:57:28Z |
| format | Article |
| id | doaj.art-cfea98b0b64f4c5f9cebb0bea87b4321 |
| institution | Directory Open Access Journal |
| issn | 2537-6373 2537-6381 |
| language | English |
| last_indexed | 2024-12-11T02:57:28Z |
| publishDate | 2020-10-01 |
| publisher | Scientific Medical Association of Moldova |
| record_format | Article |
| series | The Moldovan Medical Journal |
| spelling | doaj.art-cfea98b0b64f4c5f9cebb0bea87b43212022-12-22T01:23:08ZengScientific Medical Association of MoldovaThe Moldovan Medical Journal2537-63732537-63812020-10-01634273410.5281/zenodo.4016808Macrophages and dendritic cells density correlates with depth of invasion in the prostate carcinomaTatiana Globa0https://orcid.org/0000-0002-5317-2776Lilian Globa1https://orcid.org/0000-0001-9743-1680Valeriu David2https://orcid.org/0000-0001-9799-7369Pavel Globa3https://orcid.org/0000-0001-9399-6473Elina Pelin4https://orcid.org/0000-0002-1068-6785Lilian Saptefrati5https://orcid.org/0000-0003-2779-718XDepartment of Histology, Cytology and Embryology, Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau, the Republic of MoldovaDepartment of Clinical Anatomy, Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau, the Republic of MoldovaDepartment of Histology, Cytology and Embryology, Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau, the Republic of MoldovaDepartment of Biochemistry and Clinical Biochemistry, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, the Republic of MoldovaDepartment of Histology, Cytology and Embryology, Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau, the Republic of MoldovaDepartment of Histology, Cytology and Embryology, Nicolae Testemitsanu State University of Medicine and Pharmacy, Chisinau, the Republic of MoldovaBackground: Immune cells interact not only with tumor cells but also with stromal cells facilitating the progression of neoplasia. The ongoing battle between immune cells and the tumor is an important factor influencing the clinical course and outcome of treatment in various types of cancer. The aim of the study was to identify the prognostic value of dendritic cells and macrophages in prostate carcinoma. Material and methods: This retrospective study analyzed 73 samples of prostate cancer. The macrophages and dendritic cells have been evaluated using the immunohistochemical methods with CD68 (macrophages) and S100 (dendritic cells). Macrophages were quantified as intratumoral and peritumoral, and dendritic cells – intraepithelial and stromal. The results were analyzed statistically. Results: For evaluation of the prognostic impact of immune cells was accomplished a correlation between the total number of CD68+/S100+ cells and the Gleason score. Thus, statistically significant correlations were obtained both for CD68+ cells (intratumoral p=0.008, peritumoral p=0.001), and for S100+ cells (intraepithelial p=0.036, stromal p=0.042). In addition, a statistically significant positive linear correlation was observed between the density of intraepithelial S100+ cells and intratumoral CD68+ cells (p=0.018). Conclusions: The increase in the density of S100+ and CD68+ cells, as well as the significant association of their density with the histological degree of the tumor allow us to consider these cells as predictive biomarkers in prostate carcinomas.http://moldmedjournal.md/wp-content/uploads/2020/09/moldovan-med-j-2020-63-4-globa-et-al-full-text.pdfprostate cancerdendritic cells |
| spellingShingle | Tatiana Globa Lilian Globa Valeriu David Pavel Globa Elina Pelin Lilian Saptefrati Macrophages and dendritic cells density correlates with depth of invasion in the prostate carcinoma The Moldovan Medical Journal prostate cancer dendritic cells |
| title | Macrophages and dendritic cells density correlates with depth of invasion in the prostate carcinoma |
| title_full | Macrophages and dendritic cells density correlates with depth of invasion in the prostate carcinoma |
| title_fullStr | Macrophages and dendritic cells density correlates with depth of invasion in the prostate carcinoma |
| title_full_unstemmed | Macrophages and dendritic cells density correlates with depth of invasion in the prostate carcinoma |
| title_short | Macrophages and dendritic cells density correlates with depth of invasion in the prostate carcinoma |
| title_sort | macrophages and dendritic cells density correlates with depth of invasion in the prostate carcinoma |
| topic | prostate cancer dendritic cells |
| url | http://moldmedjournal.md/wp-content/uploads/2020/09/moldovan-med-j-2020-63-4-globa-et-al-full-text.pdf |
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