ABCA8-mediated efflux of taurocholic acid contributes to gemcitabine insensitivity in human pancreatic cancer via the S1PR2-ERK pathway

ABCA8-mediated efflux of taurocholic acid contributes to gemcitabine insensitivity in human pancreatic cancer via the S1PR2-ERK pathway

Abstract The development of resistance to anticancer drugs is believed to cause chemotherapy failure in pancreatic cancer (PC). The efflux of anticancer drugs mediated by ATP-binding cassette (ABC) transporters is a widely accepted mechanism for chemoresistance, but for ABCA subfamily members, which...

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Bibliographic Details
Main Authors: Chunmei Yang, Hui Yuan, Jinyang Gu, Dengfei Xu, Mingwei Wang, Jie Qiao, Xi Yang, Jian Zhang, Ming Yao, Jianren Gu, Hong Tu, Yu Gan
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-020-00390-z

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