Triiodothyronine (T3) Induces Limited Transcriptional and DNA Methylation Reprogramming in Human Monocytes

Triiodothyronine (T3) Induces Limited Transcriptional and DNA Methylation Reprogramming in Human Monocytes

Thyroid hormones have immunomodulatory roles, but their effects on the transcriptome and epigenome of innate immune cell types remain unexplored. In this study, we investigate the effects of triiodothyronine (T3) on the transcriptome and methylome of human monocytes in vitro, both in resting and lip...

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Bibliographic Details
Main Authors: Rebecca Shepherd, Bowon Kim, Richard Saffery, Boris Novakovic
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Biomedicines
Subjects:
monocytes
thyroid hormone
T3
triiodothyronine
DNA methylation
transcriptome
Online Access:https://www.mdpi.com/2227-9059/10/3/608

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