A single pair of neurons modulates egg-laying decisions in Drosophila.
Animals have to judge environmental cues and choose the most suitable option for them from many different options. Female fruit flies selecting an optimum site to deposit their eggs is a biologically important reproductive behavior. When given the direct choice between ovipositing their eggs in a su...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2015-01-01
|
| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4363143?pdf=render |
| _version_ | 1818486450808684544 |
|---|---|
| author | Chia-Lin Wu Tsai-Feng Fu Yen-Yun Chou Sheng-Rong Yeh |
| author_facet | Chia-Lin Wu Tsai-Feng Fu Yen-Yun Chou Sheng-Rong Yeh |
| author_sort | Chia-Lin Wu |
| collection | DOAJ |
| description | Animals have to judge environmental cues and choose the most suitable option for them from many different options. Female fruit flies selecting an optimum site to deposit their eggs is a biologically important reproductive behavior. When given the direct choice between ovipositing their eggs in a sucrose-containing medium or a caffeine-containing medium, female flies prefer the latter. However, the neural circuits and molecules that regulate this decision-making processes during egg-laying site selection remain poorly understood. In the present study, we found that amnesiac (amn) mutant flies show significant defects in egg-laying decisions, and such defects can be reversed by expressing the wild-type amn transgene in two dorsal paired medial (DPM) neurons in the brain. Silencing neuronal activity with an inward rectifier potassium channel (Kir2.1) in DPM neurons also impairs egg-laying decisions. Finally, the activity in mushroom body αβ neurons is required for the egg-laying behavior, suggesting a possible "DPM-αβ neurons" brain circuit modulating egg-laying decisions. Our results highlight the brain circuits and molecular mechanisms of egg-laying decisions in Drosophila. |
| first_indexed | 2024-12-10T16:23:11Z |
| format | Article |
| id | doaj.art-cff212fb5c4e4c69ba951fa67194e92c |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-10T16:23:11Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-cff212fb5c4e4c69ba951fa67194e92c2022-12-22T01:41:45ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01103e012133510.1371/journal.pone.0121335A single pair of neurons modulates egg-laying decisions in Drosophila.Chia-Lin WuTsai-Feng FuYen-Yun ChouSheng-Rong YehAnimals have to judge environmental cues and choose the most suitable option for them from many different options. Female fruit flies selecting an optimum site to deposit their eggs is a biologically important reproductive behavior. When given the direct choice between ovipositing their eggs in a sucrose-containing medium or a caffeine-containing medium, female flies prefer the latter. However, the neural circuits and molecules that regulate this decision-making processes during egg-laying site selection remain poorly understood. In the present study, we found that amnesiac (amn) mutant flies show significant defects in egg-laying decisions, and such defects can be reversed by expressing the wild-type amn transgene in two dorsal paired medial (DPM) neurons in the brain. Silencing neuronal activity with an inward rectifier potassium channel (Kir2.1) in DPM neurons also impairs egg-laying decisions. Finally, the activity in mushroom body αβ neurons is required for the egg-laying behavior, suggesting a possible "DPM-αβ neurons" brain circuit modulating egg-laying decisions. Our results highlight the brain circuits and molecular mechanisms of egg-laying decisions in Drosophila.http://europepmc.org/articles/PMC4363143?pdf=render |
| spellingShingle | Chia-Lin Wu Tsai-Feng Fu Yen-Yun Chou Sheng-Rong Yeh A single pair of neurons modulates egg-laying decisions in Drosophila. PLoS ONE |
| title | A single pair of neurons modulates egg-laying decisions in Drosophila. |
| title_full | A single pair of neurons modulates egg-laying decisions in Drosophila. |
| title_fullStr | A single pair of neurons modulates egg-laying decisions in Drosophila. |
| title_full_unstemmed | A single pair of neurons modulates egg-laying decisions in Drosophila. |
| title_short | A single pair of neurons modulates egg-laying decisions in Drosophila. |
| title_sort | single pair of neurons modulates egg laying decisions in drosophila |
| url | http://europepmc.org/articles/PMC4363143?pdf=render |
| work_keys_str_mv | AT chialinwu asinglepairofneuronsmodulatesegglayingdecisionsindrosophila AT tsaifengfu asinglepairofneuronsmodulatesegglayingdecisionsindrosophila AT yenyunchou asinglepairofneuronsmodulatesegglayingdecisionsindrosophila AT shengrongyeh asinglepairofneuronsmodulatesegglayingdecisionsindrosophila AT chialinwu singlepairofneuronsmodulatesegglayingdecisionsindrosophila AT tsaifengfu singlepairofneuronsmodulatesegglayingdecisionsindrosophila AT yenyunchou singlepairofneuronsmodulatesegglayingdecisionsindrosophila AT shengrongyeh singlepairofneuronsmodulatesegglayingdecisionsindrosophila |