Applications of resveratrol in the treatment of gastrointestinal cancer
Natural product compounds have lately attracted interest in the scientific community as a possible treatment for gastrointestinal (GI) cancer, due to their anti-inflammatory and anticancer properties. There are many preclinical, clinical, and epidemiological studies, suggesting that the consumption...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222006631 |
| _version_ | 1811337916670017536 |
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| author | Mohammad Roshani Ameneh Jafari Amirhossein Loghman Amir Hossein Sheida Taranomsadat Taghavi Seyed Saeed Tamehri Zadeh Michael R. Hamblin Mina Homayounfal Hamed Mirzaei |
| author_facet | Mohammad Roshani Ameneh Jafari Amirhossein Loghman Amir Hossein Sheida Taranomsadat Taghavi Seyed Saeed Tamehri Zadeh Michael R. Hamblin Mina Homayounfal Hamed Mirzaei |
| author_sort | Mohammad Roshani |
| collection | DOAJ |
| description | Natural product compounds have lately attracted interest in the scientific community as a possible treatment for gastrointestinal (GI) cancer, due to their anti-inflammatory and anticancer properties. There are many preclinical, clinical, and epidemiological studies, suggesting that the consumption of polyphenol compounds, which are abundant in vegetables, grains, fruits, and pulses, may help to prevent various illnesses and disorders from developing, including several GI cancers. The development of GI malignancies follows a well-known path, in which normal gastrointestinal cells acquire abnormalities in their genetic composition, causing the cells to continuously proliferate, and metastasize to other sites, especially the brain and liver. Natural compounds with the ability to affect oncogenic pathways might be possible treatments for GI malignancies, and could easily be tested in clinical trials. Resveratrol is a non-flavonoid polyphenol and a natural stilbene, acting as a phytoestrogen with anti-cancer, cardioprotective, anti-oxidant, and anti-inflammatory properties. Resveratrol has been shown to overcome resistance mechanisms in cancer cells, and when combined with conventional anticancer drugs, could sensitize cancer cells to chemotherapy. Several new resveratrol analogs and nanostructured delivery vehicles with improved anti-GI cancer efficacy, absorption, and pharmacokinetic profiles have already been developed. This present review focuses on the in vitro and in vivo effects of resveratrol on GI cancers, as well as the underlying molecular mechanisms of action. |
| first_indexed | 2024-04-13T18:02:59Z |
| format | Article |
| id | doaj.art-cff272d6f17d43fe8be1b9627cfde35e |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-13T18:02:59Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-cff272d6f17d43fe8be1b9627cfde35e2022-12-22T02:36:12ZengElsevierBiomedicine & Pharmacotherapy0753-33222022-09-01153113274Applications of resveratrol in the treatment of gastrointestinal cancerMohammad Roshani0Ameneh Jafari1Amirhossein Loghman2Amir Hossein Sheida3Taranomsadat Taghavi4Seyed Saeed Tamehri Zadeh5Michael R. Hamblin6Mina Homayounfal7Hamed Mirzaei8Internal Medicine and Gastroenterology, Colorectal Research Center, Iran University of Medical Sciences, Tehran, IranAdvanced Therapy Medicinal Product (ATMP) Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran; Proteomics Research Center, Shahid Beheshti University of Medical Sciences, Tehran, IranSchool of Medicine, Kashan University of Medical Sciences, Kashan, IranSchool of Medicine, Kashan University of Medical Sciences, Kashan, Iran; Student Research Committee, Kashan University of Medical Sciences, Kashan, IranDepartment of Cell and Moleclar Biology, University of Tehran, Tehran, IranSchool of Medicine, Tehran University of Medical Sciences, Tehran, IranLaser Research Centre, Faculty of Health Science, University of Johannesburg, Doornfontein 2028, South AfricaResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, IranResearch Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran; Correspondence to: Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran.Natural product compounds have lately attracted interest in the scientific community as a possible treatment for gastrointestinal (GI) cancer, due to their anti-inflammatory and anticancer properties. There are many preclinical, clinical, and epidemiological studies, suggesting that the consumption of polyphenol compounds, which are abundant in vegetables, grains, fruits, and pulses, may help to prevent various illnesses and disorders from developing, including several GI cancers. The development of GI malignancies follows a well-known path, in which normal gastrointestinal cells acquire abnormalities in their genetic composition, causing the cells to continuously proliferate, and metastasize to other sites, especially the brain and liver. Natural compounds with the ability to affect oncogenic pathways might be possible treatments for GI malignancies, and could easily be tested in clinical trials. Resveratrol is a non-flavonoid polyphenol and a natural stilbene, acting as a phytoestrogen with anti-cancer, cardioprotective, anti-oxidant, and anti-inflammatory properties. Resveratrol has been shown to overcome resistance mechanisms in cancer cells, and when combined with conventional anticancer drugs, could sensitize cancer cells to chemotherapy. Several new resveratrol analogs and nanostructured delivery vehicles with improved anti-GI cancer efficacy, absorption, and pharmacokinetic profiles have already been developed. This present review focuses on the in vitro and in vivo effects of resveratrol on GI cancers, as well as the underlying molecular mechanisms of action.http://www.sciencedirect.com/science/article/pii/S0753332222006631ResveratrolGastrointestinal cancerTherapyNanoformulation |
| spellingShingle | Mohammad Roshani Ameneh Jafari Amirhossein Loghman Amir Hossein Sheida Taranomsadat Taghavi Seyed Saeed Tamehri Zadeh Michael R. Hamblin Mina Homayounfal Hamed Mirzaei Applications of resveratrol in the treatment of gastrointestinal cancer Biomedicine & Pharmacotherapy Resveratrol Gastrointestinal cancer Therapy Nanoformulation |
| title | Applications of resveratrol in the treatment of gastrointestinal cancer |
| title_full | Applications of resveratrol in the treatment of gastrointestinal cancer |
| title_fullStr | Applications of resveratrol in the treatment of gastrointestinal cancer |
| title_full_unstemmed | Applications of resveratrol in the treatment of gastrointestinal cancer |
| title_short | Applications of resveratrol in the treatment of gastrointestinal cancer |
| title_sort | applications of resveratrol in the treatment of gastrointestinal cancer |
| topic | Resveratrol Gastrointestinal cancer Therapy Nanoformulation |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222006631 |
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