HLA-B*57:01 Complexed to a CD8 T-Cell Epitope from the HSV-2 ICP22 Protein Binds NK and T Cells through KIR3DL1

HLA-B*57:01 Complexed to a CD8 T-Cell Epitope from the HSV-2 ICP22 Protein Binds NK and T Cells through KIR3DL1

HLA-B*57:01 is an HLA allelic variant associated with positive outcomes during viral infections through interactions with T cells and NK cells, but severe disease in persons treated with the anti-HIV-1 drug abacavir. The role of HLA-B*57:01 in the context of HSV infection is unknown. We identified a...

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Bibliographic Details
Main Authors: Kerry J. Laing, Victoria L. Campbell, Lichun Dong, David M. Koelle
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Viruses
Subjects:
CD8 T cell
T-cell epitope
NK cell
KIR3DL1
HLA-B*57:01
herpes simplex virus
Online Access:https://www.mdpi.com/1999-4915/14/5/1019

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