<italic toggle="yes">Candida albicans</italic> Genetic Background Influences Mean and Heterogeneity of Drug Responses and Genome Stability during Evolution in Fluconazole

<italic toggle="yes">Candida albicans</italic> Genetic Background Influences Mean and Heterogeneity of Drug Responses and Genome Stability during Evolution in Fluconazole

ABSTRACT The importance of within-species diversity in determining the evolutionary potential of a population to evolve drug resistance or tolerance is not well understood, including in eukaryotic pathogens. To examine the influence of genetic background, we evolved replicates of 20 different clinic...

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Bibliographic Details
Main Authors: Aleeza C. Gerstein, Judith Berman
Format: Article
Language:English
Published: American Society for Microbiology 2020-06-01
Series:mSphere
Subjects:
AMR
fitness
ploidy
Online Access:https://journals.asm.org/doi/10.1128/mSphere.00480-20

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