Efficient 1-Hydroxy-2-Butanone Production from 1,2-Butanediol by Whole Cells of Engineered <i>E. coli</i>

Efficient 1-Hydroxy-2-Butanone Production from 1,2-Butanediol by Whole Cells of Engineered <i>E. coli</i>

1-Hydroxy-2-butanone (HB) is a key intermediate for anti-tuberculosis pharmaceutical ethambutol. Commercially available HB is primarily obtained by the oxidation of 1,2-butanediol (1,2-BD) using chemical catalysts. In present study, seven enzymes including diol dehydrogenases, secondary alcohol dehy...

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Bibliographic Details
Main Authors: Hui Lin, Jiayin Xu, Wenlian Sun, Wujia Hu, Huifang Gao, Kaihui Hu, Junzhi Qiu, Binbin Huang, Liaoyuan Zhang
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Catalysts
Subjects:
1-hydroxy-2-butanone
1,2-butanediol
diol dehydrogenase
whole cell biocatalysis
chiral resolution
Online Access:https://www.mdpi.com/2073-4344/11/10/1184

Internet

https://www.mdpi.com/2073-4344/11/10/1184

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