New Insights Into the Effects of Individual Chinese Herbal Medicines on Chronic Kidney Disease
The clinical and experimental study into the effects of Chinese herbal medicines on chronic kidney disease has evolved over the past 40 years with new insight into their mechanism and evidence of their clinical effects. Among the many traditional Chinese herbs examined in chronic renal disease, five...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2021.774414/full |
| _version_ | 1818851379190431744 |
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| author | Minghai Shao Chaoyang Ye George Bayliss Shougang Zhuang Shougang Zhuang |
| author_facet | Minghai Shao Chaoyang Ye George Bayliss Shougang Zhuang Shougang Zhuang |
| author_sort | Minghai Shao |
| collection | DOAJ |
| description | The clinical and experimental study into the effects of Chinese herbal medicines on chronic kidney disease has evolved over the past 40 years with new insight into their mechanism and evidence of their clinical effects. Among the many traditional Chinese herbs examined in chronic renal disease, five were found to have evidence of sufficient clinical efficacy, high frequency of use, and well-studied mechanism. They are: Abelmoschus manihot and Huangkui capsule, Salvia miltiorrhiza and its components (tanshinone II A, salvianolic acid A and B); Rhizoma coptidis and its monomer berberine; Tripterygium wilfordii and its components (triptolide, tripterygium glycosides); Kudzu root Pueraria and its monomer Puerarin. These Chinese herbal medications have pharmaceutical effects against fibrosis, inflammation and oxidative stress and also promote renal repair and regeneration. This article reviews their clinical efficacy, anti-fibrotic effects in animal models, and molecular mechanism of action. |
| first_indexed | 2024-12-19T07:04:05Z |
| format | Article |
| id | doaj.art-cff61ecacd6a498292188c8c2df97140 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-19T07:04:05Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-cff61ecacd6a498292188c8c2df971402022-12-21T20:31:21ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122021-11-011210.3389/fphar.2021.774414774414New Insights Into the Effects of Individual Chinese Herbal Medicines on Chronic Kidney DiseaseMinghai Shao0Chaoyang Ye1George Bayliss2Shougang Zhuang3Shougang Zhuang4Department of Nephrology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Nephrology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Medicine, Rhode Island Hospital and Alpert Medical School, Brown University, Providence, RI, United StatesDepartment of Medicine, Rhode Island Hospital and Alpert Medical School, Brown University, Providence, RI, United StatesDepartment of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, ChinaThe clinical and experimental study into the effects of Chinese herbal medicines on chronic kidney disease has evolved over the past 40 years with new insight into their mechanism and evidence of their clinical effects. Among the many traditional Chinese herbs examined in chronic renal disease, five were found to have evidence of sufficient clinical efficacy, high frequency of use, and well-studied mechanism. They are: Abelmoschus manihot and Huangkui capsule, Salvia miltiorrhiza and its components (tanshinone II A, salvianolic acid A and B); Rhizoma coptidis and its monomer berberine; Tripterygium wilfordii and its components (triptolide, tripterygium glycosides); Kudzu root Pueraria and its monomer Puerarin. These Chinese herbal medications have pharmaceutical effects against fibrosis, inflammation and oxidative stress and also promote renal repair and regeneration. This article reviews their clinical efficacy, anti-fibrotic effects in animal models, and molecular mechanism of action.https://www.frontiersin.org/articles/10.3389/fphar.2021.774414/fullrenal fibrosisChinese herbsmonomerschronic kidney diseaseAbelmoschus manihotSalvia miltiorrhiza |
| spellingShingle | Minghai Shao Chaoyang Ye George Bayliss Shougang Zhuang Shougang Zhuang New Insights Into the Effects of Individual Chinese Herbal Medicines on Chronic Kidney Disease Frontiers in Pharmacology renal fibrosis Chinese herbs monomers chronic kidney disease Abelmoschus manihot Salvia miltiorrhiza |
| title | New Insights Into the Effects of Individual Chinese Herbal Medicines on Chronic Kidney Disease |
| title_full | New Insights Into the Effects of Individual Chinese Herbal Medicines on Chronic Kidney Disease |
| title_fullStr | New Insights Into the Effects of Individual Chinese Herbal Medicines on Chronic Kidney Disease |
| title_full_unstemmed | New Insights Into the Effects of Individual Chinese Herbal Medicines on Chronic Kidney Disease |
| title_short | New Insights Into the Effects of Individual Chinese Herbal Medicines on Chronic Kidney Disease |
| title_sort | new insights into the effects of individual chinese herbal medicines on chronic kidney disease |
| topic | renal fibrosis Chinese herbs monomers chronic kidney disease Abelmoschus manihot Salvia miltiorrhiza |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2021.774414/full |
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