Frequency-potency analysis of IgG+ memory B cells delineates neutralizing antibody responses at single-cell resolution

Frequency-potency analysis of IgG+ memory B cells delineates neutralizing antibody responses at single-cell resolution

Summary: Identifying individual functional B cell receptors (BCRs) is common, but two-dimensional analysis of B cell frequency versus BCR potency would delineate both quantity and quality of antigen-specific memory B cells. We efficiently determine quantitative BCR neutralizing activities using a si...

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Bibliographic Details
Main Authors: Michelle K. Tenggara, Seo-Ho Oh, Catherine Yang, Hardik K. Nariya, Amanda M. Metz, Amit A. Upadhyay, Dedeepya R. Gudipati, Lizheng Guo, Emily G. McGhee, Kiran Gill, Elise G. Viox, Rosemarie D. Mason, Nicole A. Doria-Rose, Kathryn E. Foulds, John R. Mascola, Yuhong Du, Haian Fu, John D. Altman, Qi Yan, Zizhang Sheng, Steven E. Bosinger, Rui Kong
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124724002766

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