Combined test versus logrank/Cox test in 50 randomised trials

Combined test versus logrank/Cox test in 50 randomised trials

Abstract Background The logrank test and the Cox proportional hazards model are routinely applied in the design and analysis of randomised controlled trials (RCTs) with time-to-event outcomes. Usually, sample size and power calculations assume proportional hazards (PH) of the treatment effect, i.e....

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Bibliographic Details
Main Authors: Patrick Royston, Babak Choodari-Oskooei, Mahesh K. B. Parmar, Jennifer K. Rogers
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Trials
Subjects:
Randomised controlled trials
Time-to-event outcome
Logrank test
Cox test
Hazard ratio
Non-proportional hazards
Online Access:http://link.springer.com/article/10.1186/s13063-019-3251-5

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