Visual properties of human retinal ganglion cells.
The retinal output is the sole source of visual information for the brain. Studies in non-primate mammals estimate that this information is carried by several dozens of retinal ganglion cell types, each informing the brain about different aspects of a visual scene. Even though morphological studies...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2021-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0246952 |
| _version_ | 1818891855368028160 |
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| author | Katja Reinhard Thomas A Münch |
| author_facet | Katja Reinhard Thomas A Münch |
| author_sort | Katja Reinhard |
| collection | DOAJ |
| description | The retinal output is the sole source of visual information for the brain. Studies in non-primate mammals estimate that this information is carried by several dozens of retinal ganglion cell types, each informing the brain about different aspects of a visual scene. Even though morphological studies of primate retina suggest a similar diversity of ganglion cell types, research has focused on the function of only a few cell types. In human retina, recordings from individual cells are anecdotal or focus on a small subset of identified types. Here, we present the first systematic ex-vivo recording of light responses from 342 ganglion cells in human retinas obtained from donors. We find a great variety in the human retinal output in terms of preferences for positive or negative contrast, spatio-temporal frequency encoding, contrast sensitivity, and speed tuning. Some human ganglion cells showed similar response behavior as known cell types in other primate retinas, while we also recorded light responses that have not been described previously. This first extensive description of the human retinal output should facilitate interpretation of primate data and comparison to other mammalian species, and it lays the basis for the use of ex-vivo human retina for in-vitro analysis of novel treatment approaches. |
| first_indexed | 2024-12-19T17:47:26Z |
| format | Article |
| id | doaj.art-cffa784bb5124efdbf5398b10f212f29 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-19T17:47:26Z |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-cffa784bb5124efdbf5398b10f212f292022-12-21T20:12:01ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01162e024695210.1371/journal.pone.0246952Visual properties of human retinal ganglion cells.Katja ReinhardThomas A MünchThe retinal output is the sole source of visual information for the brain. Studies in non-primate mammals estimate that this information is carried by several dozens of retinal ganglion cell types, each informing the brain about different aspects of a visual scene. Even though morphological studies of primate retina suggest a similar diversity of ganglion cell types, research has focused on the function of only a few cell types. In human retina, recordings from individual cells are anecdotal or focus on a small subset of identified types. Here, we present the first systematic ex-vivo recording of light responses from 342 ganglion cells in human retinas obtained from donors. We find a great variety in the human retinal output in terms of preferences for positive or negative contrast, spatio-temporal frequency encoding, contrast sensitivity, and speed tuning. Some human ganglion cells showed similar response behavior as known cell types in other primate retinas, while we also recorded light responses that have not been described previously. This first extensive description of the human retinal output should facilitate interpretation of primate data and comparison to other mammalian species, and it lays the basis for the use of ex-vivo human retina for in-vitro analysis of novel treatment approaches.https://doi.org/10.1371/journal.pone.0246952 |
| spellingShingle | Katja Reinhard Thomas A Münch Visual properties of human retinal ganglion cells. PLoS ONE |
| title | Visual properties of human retinal ganglion cells. |
| title_full | Visual properties of human retinal ganglion cells. |
| title_fullStr | Visual properties of human retinal ganglion cells. |
| title_full_unstemmed | Visual properties of human retinal ganglion cells. |
| title_short | Visual properties of human retinal ganglion cells. |
| title_sort | visual properties of human retinal ganglion cells |
| url | https://doi.org/10.1371/journal.pone.0246952 |
| work_keys_str_mv | AT katjareinhard visualpropertiesofhumanretinalganglioncells AT thomasamunch visualpropertiesofhumanretinalganglioncells |