Structure of <i>Leishmania donovani</i> 6-Phosphogluconate Dehydrogenase and Inhibition by Phosphine Gold(I) Complexes: A Potential Approach to Leishmaniasis Treatment

Structure of <i>Leishmania donovani</i> 6-Phosphogluconate Dehydrogenase and Inhibition by Phosphine Gold(I) Complexes: A Potential Approach to Leishmaniasis Treatment

As unicellular parasites are highly dependent on NADPH as a source for reducing equivalents, the main NADPH-producing enzymes glucose 6-phosphate dehydrogenase (G6PD) and 6-phosphogluconate dehydrogenase (6PGD) of the pentose phosphate pathway are considered promising antitrypanosomatid drug targets...

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Bibliographic Details
Main Authors:	Isabell Berneburg, Michaela Stumpf, Ann-Sophie Velten, Stefan Rahlfs, Jude Przyborski, Katja Becker, Karin Fritz-Wolf
Format:	Article
Language:	English
Published:	MDPI AG 2023-05-01
Series:	International Journal of Molecular Sciences
Subjects:	leishmaniasis 6-phosphogluconate dehydrogenase pentose phosphate pathway auranofin phosphine gold(I)-complexes
Online Access:	https://www.mdpi.com/1422-0067/24/10/8615

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