Histopathological changes in gallbladder mucosa associated with cholelithiasis
<p><strong>Background: </strong>Gallstone is a very common gastrointestinal disorder. It is known to produce histopathological changes in the gallbladder. It is also one of the predisposing factors for the development of cancer of gallbladder.</p> <p><strong>Mater...
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| Format: | Article |
| Language: | English |
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Association of Clinical Pathologists of Nepal
2012-03-01
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| Series: | Journal of Pathology of Nepal |
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| Online Access: | http://www.nepjol.info/index.php/JPN/article/view/6027 |
| _version_ | 1818927124592984064 |
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| author | R Baidya B Sigdel NL Baidya |
| author_facet | R Baidya B Sigdel NL Baidya |
| author_sort | R Baidya |
| collection | DOAJ |
| description | <p><strong>Background: </strong>Gallstone is a very common gastrointestinal disorder. It is known to produce histopathological changes in the gallbladder. It is also one of the predisposing factors for the development of cancer of gallbladder.</p> <p><strong>Materials and Methods: </strong>This was a retrospective study carried out in the Department of Histopathology, B and B Hospital during a period of 1 year from April 2010 to May 2011. The study included 396 cases of cholecystectomy specimens.</p> <p><strong>Results: </strong>On gross examination, outer gallbladder surface was congested in 116 patients (28%), wall thickness was increased in 181 (45.7%) and mucosal abnormalities were present in 126 (31.6%) patients. At microscopy, epithelial hyperplasia was observed in 183 (46.2%), intestinal metaplasia in 112 (28.2%), dysplasia in 5 (1.3%) and cholesterolosis in 56 (14%) patients.</p> <p><strong>Conclusion: </strong>The pathological changes of the gallbladder epithelium may play an important role in the process of gallstone formation.<strong></strong></p> <p>DOI: <a href="http://dx.doi.org/10.3126/jpn.v2i3.6027">http://dx.doi.org/10.3126/jpn.v2i3.6027</a></p> <p><em>JPN </em>2012; 2(3): 224-225<strong></strong></p> |
| first_indexed | 2024-12-20T03:08:02Z |
| format | Article |
| id | doaj.art-cffd22767b2c4d75bac902b349d3f7fe |
| institution | Directory Open Access Journal |
| issn | 2091-0797 2091-0908 |
| language | English |
| last_indexed | 2024-12-20T03:08:02Z |
| publishDate | 2012-03-01 |
| publisher | Association of Clinical Pathologists of Nepal |
| record_format | Article |
| series | Journal of Pathology of Nepal |
| spelling | doaj.art-cffd22767b2c4d75bac902b349d3f7fe2022-12-21T19:55:33ZengAssociation of Clinical Pathologists of NepalJournal of Pathology of Nepal2091-07972091-09082012-03-012322422510.3126/jpn.v2i3.60274887Histopathological changes in gallbladder mucosa associated with cholelithiasisR Baidya0B Sigdel1NL Baidya2Department of Pathology, B and B Hospital, LalitpurDepartment of Pathology, B and B Hospital, LalitpurDepartment of Pathology, B and B Hospital, Lalitpur<p><strong>Background: </strong>Gallstone is a very common gastrointestinal disorder. It is known to produce histopathological changes in the gallbladder. It is also one of the predisposing factors for the development of cancer of gallbladder.</p> <p><strong>Materials and Methods: </strong>This was a retrospective study carried out in the Department of Histopathology, B and B Hospital during a period of 1 year from April 2010 to May 2011. The study included 396 cases of cholecystectomy specimens.</p> <p><strong>Results: </strong>On gross examination, outer gallbladder surface was congested in 116 patients (28%), wall thickness was increased in 181 (45.7%) and mucosal abnormalities were present in 126 (31.6%) patients. At microscopy, epithelial hyperplasia was observed in 183 (46.2%), intestinal metaplasia in 112 (28.2%), dysplasia in 5 (1.3%) and cholesterolosis in 56 (14%) patients.</p> <p><strong>Conclusion: </strong>The pathological changes of the gallbladder epithelium may play an important role in the process of gallstone formation.<strong></strong></p> <p>DOI: <a href="http://dx.doi.org/10.3126/jpn.v2i3.6027">http://dx.doi.org/10.3126/jpn.v2i3.6027</a></p> <p><em>JPN </em>2012; 2(3): 224-225<strong></strong></p>http://www.nepjol.info/index.php/JPN/article/view/6027CholelithiasisDysplasiaEpithelial hyperplasia |
| spellingShingle | R Baidya B Sigdel NL Baidya Histopathological changes in gallbladder mucosa associated with cholelithiasis Journal of Pathology of Nepal Cholelithiasis Dysplasia Epithelial hyperplasia |
| title | Histopathological changes in gallbladder mucosa associated with cholelithiasis |
| title_full | Histopathological changes in gallbladder mucosa associated with cholelithiasis |
| title_fullStr | Histopathological changes in gallbladder mucosa associated with cholelithiasis |
| title_full_unstemmed | Histopathological changes in gallbladder mucosa associated with cholelithiasis |
| title_short | Histopathological changes in gallbladder mucosa associated with cholelithiasis |
| title_sort | histopathological changes in gallbladder mucosa associated with cholelithiasis |
| topic | Cholelithiasis Dysplasia Epithelial hyperplasia |
| url | http://www.nepjol.info/index.php/JPN/article/view/6027 |
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