Association of the polymorphisms of the cholesteryl ester transfer protein gene with coronary artery disease: a meta-analysis
AimsThis meta-analysis aimed to assess the association of the polymorphisms of cholesterol ester transfer protein (CETP) rs708272 (G>A), rs5882 (G>A), rs1800775 (C>A), rs4783961 (G>A), rs247616 (C>T), rs5883 (C>T), rs1800776 (C>A), and rs1532624 (C&am...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1260679/full |
| _version_ | 1797401576713748480 |
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| author | Ruizhe Zhang Qingya Xie Pingxi Xiao |
| author_facet | Ruizhe Zhang Qingya Xie Pingxi Xiao |
| author_sort | Ruizhe Zhang |
| collection | DOAJ |
| description | AimsThis meta-analysis aimed to assess the association of the polymorphisms of cholesterol ester transfer protein (CETP) rs708272 (G>A), rs5882 (G>A), rs1800775 (C>A), rs4783961 (G>A), rs247616 (C>T), rs5883 (C>T), rs1800776 (C>A), and rs1532624 (C>A) with coronary artery disease (CAD) and the related underlying mechanisms.MethodsA comprehensive search was performed using five databases such as PubMed, EMBASE, Web of Science, Cochrane Library and Scopus to obtain the appropriate articles. The quality of the included studies was assessed by the Newcastle-Ottawa Scale. The statistical analysis of the data was performed using STATA 17.0 software. The association between CETP gene polymorphisms and risk of CAD was estimated using the pooled odds ratio (OR) and 95% confidence interval (95% CI). The association of CETP gene polymorphisms with lipids and with CETP levels was assessed using the pooled standardized mean difference and corresponding 95% CI. P < 0.05 was considered statistically significant.ResultsA total of 70 case-control studies with 30,619 cases and 31,836 controls from 46 articles were included. The results showed the CETP rs708272 polymorphism was significantly associated with a reduced risk of CAD under the allele model (OR = 0.846, P < 0.001), the dominant model (OR = 0.838, P < 0.001) and the recessive model (OR = 0.758, P < 0.001). AA genotype and GA genotype corresponded to higher high-density lipoprotein cholesterol (HDL-C) concentrations in the blood compared with GG genotype across the studied groups (all P < 0.05). The CETP rs5882 and rs1800775 polymorphisms were not significantly associated with CAD under the allele model (P = 0.802, P = 0.392), the dominant model (P = 0.556, P = 0.183) and the recessive model (P = 0.429, P = 0.551). Similarly, the other mentioned gene polymorphisms were not significantly associated with CAD under the three genetic models.ConclusionsThe CETP rs708272 polymorphism shows a significant association with CAD, and the carriers of the allele A are associated with a lower risk of CAD and higher HDL-C concentrations in the blood compared to the non-carriers. The CETP rs5882, rs1800775, rs4783961, rs247616, rs5883, rs1800776, and rs1532624 are not significantly associated with CAD.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023432865, identifier: CRD42023432865. |
| first_indexed | 2024-03-09T02:12:07Z |
| format | Article |
| id | doaj.art-cffe522890f74d1ea2c059d3263153d3 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-03-09T02:12:07Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-cffe522890f74d1ea2c059d3263153d32023-12-07T09:46:44ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2023-12-011010.3389/fcvm.2023.12606791260679Association of the polymorphisms of the cholesteryl ester transfer protein gene with coronary artery disease: a meta-analysisRuizhe Zhang0Qingya Xie1Pingxi Xiao2Department of Cardiology, Sir Run Run, Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Cardiology, The Forth Affiliated Hospital, Nanjing Medical University, Nanjing, ChinaDepartment of Cardiology, The Forth Affiliated Hospital, Nanjing Medical University, Nanjing, ChinaAimsThis meta-analysis aimed to assess the association of the polymorphisms of cholesterol ester transfer protein (CETP) rs708272 (G>A), rs5882 (G>A), rs1800775 (C>A), rs4783961 (G>A), rs247616 (C>T), rs5883 (C>T), rs1800776 (C>A), and rs1532624 (C>A) with coronary artery disease (CAD) and the related underlying mechanisms.MethodsA comprehensive search was performed using five databases such as PubMed, EMBASE, Web of Science, Cochrane Library and Scopus to obtain the appropriate articles. The quality of the included studies was assessed by the Newcastle-Ottawa Scale. The statistical analysis of the data was performed using STATA 17.0 software. The association between CETP gene polymorphisms and risk of CAD was estimated using the pooled odds ratio (OR) and 95% confidence interval (95% CI). The association of CETP gene polymorphisms with lipids and with CETP levels was assessed using the pooled standardized mean difference and corresponding 95% CI. P < 0.05 was considered statistically significant.ResultsA total of 70 case-control studies with 30,619 cases and 31,836 controls from 46 articles were included. The results showed the CETP rs708272 polymorphism was significantly associated with a reduced risk of CAD under the allele model (OR = 0.846, P < 0.001), the dominant model (OR = 0.838, P < 0.001) and the recessive model (OR = 0.758, P < 0.001). AA genotype and GA genotype corresponded to higher high-density lipoprotein cholesterol (HDL-C) concentrations in the blood compared with GG genotype across the studied groups (all P < 0.05). The CETP rs5882 and rs1800775 polymorphisms were not significantly associated with CAD under the allele model (P = 0.802, P = 0.392), the dominant model (P = 0.556, P = 0.183) and the recessive model (P = 0.429, P = 0.551). Similarly, the other mentioned gene polymorphisms were not significantly associated with CAD under the three genetic models.ConclusionsThe CETP rs708272 polymorphism shows a significant association with CAD, and the carriers of the allele A are associated with a lower risk of CAD and higher HDL-C concentrations in the blood compared to the non-carriers. The CETP rs5882, rs1800775, rs4783961, rs247616, rs5883, rs1800776, and rs1532624 are not significantly associated with CAD.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023432865, identifier: CRD42023432865.https://www.frontiersin.org/articles/10.3389/fcvm.2023.1260679/fullcoronary artery diseasesingle nucleotide polymorphismscholesteryl ester transfer proteinmeta-analysisreview |
| spellingShingle | Ruizhe Zhang Qingya Xie Pingxi Xiao Association of the polymorphisms of the cholesteryl ester transfer protein gene with coronary artery disease: a meta-analysis Frontiers in Cardiovascular Medicine coronary artery disease single nucleotide polymorphisms cholesteryl ester transfer protein meta-analysis review |
| title | Association of the polymorphisms of the cholesteryl ester transfer protein gene with coronary artery disease: a meta-analysis |
| title_full | Association of the polymorphisms of the cholesteryl ester transfer protein gene with coronary artery disease: a meta-analysis |
| title_fullStr | Association of the polymorphisms of the cholesteryl ester transfer protein gene with coronary artery disease: a meta-analysis |
| title_full_unstemmed | Association of the polymorphisms of the cholesteryl ester transfer protein gene with coronary artery disease: a meta-analysis |
| title_short | Association of the polymorphisms of the cholesteryl ester transfer protein gene with coronary artery disease: a meta-analysis |
| title_sort | association of the polymorphisms of the cholesteryl ester transfer protein gene with coronary artery disease a meta analysis |
| topic | coronary artery disease single nucleotide polymorphisms cholesteryl ester transfer protein meta-analysis review |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2023.1260679/full |
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