NEW BIOKERATOPROSTHETIC COMPLEX BASED ON MODIFIED ALLOGENIC DONOR CORNEAS AND CULTURED POSTNATAL HUMAN SKIN FIBROBLASTS
The aim of the study was to develop biokeratoprosthetic complex based on cross-linking modified allogenic donor corneas and cultured postnatal human skin fibroblasts. Cross-linking enhances corneal strength and tole- rance to proteolytic enzymes. Fibroblasts’ proliferation and migration in the intra...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2011-06-01
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| Series: | Vestnik Transplantologii i Iskusstvennyh Organov |
| Subjects: | |
| Online Access: | https://journal.transpl.ru/vtio/article/view/418 |
| Summary: | The aim of the study was to develop biokeratoprosthetic complex based on cross-linking modified allogenic donor corneas and cultured postnatal human skin fibroblasts. Cross-linking enhances corneal strength and tole- rance to proteolytic enzymes. Fibroblasts’ proliferation and migration in the intrastromal pocket stimulates fiber syncytium formation and collagen microcarriers integration into the corneal stroma, as well as intercellular ma- trix formation around the prosthetic metallic plate as early as the cocultivation stage. A new biokeratoprosthetic complex has been successfully developed for further in vivo studies. |
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| ISSN: | 1995-1191 |