NEW BIOKERATOPROSTHETIC COMPLEX BASED ON MODIFIED ALLOGENIC DONOR CORNEAS AND CULTURED POSTNATAL HUMAN SKIN FIBROBLASTS
The aim of the study was to develop biokeratoprosthetic complex based on cross-linking modified allogenic donor corneas and cultured postnatal human skin fibroblasts. Cross-linking enhances corneal strength and tole- rance to proteolytic enzymes. Fibroblasts’ proliferation and migration in the intra...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2011-06-01
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| Series: | Vestnik Transplantologii i Iskusstvennyh Organov |
| Subjects: | |
| Online Access: | https://journal.transpl.ru/vtio/article/view/418 |
| _version_ | 1797872100427431936 |
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| author | S. A. Borzenok A. V. Vasilyev A. V. Shipunova E. B. Dashinimaev Z. I. Moroz Y. A. Komakh E. V. Kovshun |
| author_facet | S. A. Borzenok A. V. Vasilyev A. V. Shipunova E. B. Dashinimaev Z. I. Moroz Y. A. Komakh E. V. Kovshun |
| author_sort | S. A. Borzenok |
| collection | DOAJ |
| description | The aim of the study was to develop biokeratoprosthetic complex based on cross-linking modified allogenic donor corneas and cultured postnatal human skin fibroblasts. Cross-linking enhances corneal strength and tole- rance to proteolytic enzymes. Fibroblasts’ proliferation and migration in the intrastromal pocket stimulates fiber syncytium formation and collagen microcarriers integration into the corneal stroma, as well as intercellular ma- trix formation around the prosthetic metallic plate as early as the cocultivation stage. A new biokeratoprosthetic complex has been successfully developed for further in vivo studies. |
| first_indexed | 2024-04-10T00:53:25Z |
| format | Article |
| id | doaj.art-cffe86bc72854386800306e6c2b27fd9 |
| institution | Directory Open Access Journal |
| issn | 1995-1191 |
| language | Russian |
| last_indexed | 2024-04-10T00:53:25Z |
| publishDate | 2011-06-01 |
| publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
| record_format | Article |
| series | Vestnik Transplantologii i Iskusstvennyh Organov |
| spelling | doaj.art-cffe86bc72854386800306e6c2b27fd92023-03-13T10:37:21ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovVestnik Transplantologii i Iskusstvennyh Organov1995-11912011-06-01133677210.15825/1995-1191-2011-3-67-72361NEW BIOKERATOPROSTHETIC COMPLEX BASED ON MODIFIED ALLOGENIC DONOR CORNEAS AND CULTURED POSTNATAL HUMAN SKIN FIBROBLASTSS. A. Borzenok0A. V. Vasilyev1A. V. Shipunova2E. B. Dashinimaev3Z. I. Moroz4Y. A. Komakh5E. V. Kovshun6SN Fyodorov Eye Microsurgery Federal State InstitutionNK Koltsov Institute of Developmental BiologySN Fyodorov Eye Microsurgery Federal State InstitutionNK Koltsov Institute of Developmental BiologySN Fyodorov Eye Microsurgery Federal State InstitutionSN Fyodorov Eye Microsurgery Federal State InstitutionSN Fyodorov Eye Microsurgery Federal State InstitutionThe aim of the study was to develop biokeratoprosthetic complex based on cross-linking modified allogenic donor corneas and cultured postnatal human skin fibroblasts. Cross-linking enhances corneal strength and tole- rance to proteolytic enzymes. Fibroblasts’ proliferation and migration in the intrastromal pocket stimulates fiber syncytium formation and collagen microcarriers integration into the corneal stroma, as well as intercellular ma- trix formation around the prosthetic metallic plate as early as the cocultivation stage. A new biokeratoprosthetic complex has been successfully developed for further in vivo studies.https://journal.transpl.ru/vtio/article/view/418tissue engineering constructkeratoprostheticspostnatal skin fibroblastscorneal collagen crosslinking |
| spellingShingle | S. A. Borzenok A. V. Vasilyev A. V. Shipunova E. B. Dashinimaev Z. I. Moroz Y. A. Komakh E. V. Kovshun NEW BIOKERATOPROSTHETIC COMPLEX BASED ON MODIFIED ALLOGENIC DONOR CORNEAS AND CULTURED POSTNATAL HUMAN SKIN FIBROBLASTS Vestnik Transplantologii i Iskusstvennyh Organov tissue engineering construct keratoprosthetics postnatal skin fibroblasts corneal collagen crosslinking |
| title | NEW BIOKERATOPROSTHETIC COMPLEX BASED ON MODIFIED ALLOGENIC DONOR CORNEAS AND CULTURED POSTNATAL HUMAN SKIN FIBROBLASTS |
| title_full | NEW BIOKERATOPROSTHETIC COMPLEX BASED ON MODIFIED ALLOGENIC DONOR CORNEAS AND CULTURED POSTNATAL HUMAN SKIN FIBROBLASTS |
| title_fullStr | NEW BIOKERATOPROSTHETIC COMPLEX BASED ON MODIFIED ALLOGENIC DONOR CORNEAS AND CULTURED POSTNATAL HUMAN SKIN FIBROBLASTS |
| title_full_unstemmed | NEW BIOKERATOPROSTHETIC COMPLEX BASED ON MODIFIED ALLOGENIC DONOR CORNEAS AND CULTURED POSTNATAL HUMAN SKIN FIBROBLASTS |
| title_short | NEW BIOKERATOPROSTHETIC COMPLEX BASED ON MODIFIED ALLOGENIC DONOR CORNEAS AND CULTURED POSTNATAL HUMAN SKIN FIBROBLASTS |
| title_sort | new biokeratoprosthetic complex based on modified allogenic donor corneas and cultured postnatal human skin fibroblasts |
| topic | tissue engineering construct keratoprosthetics postnatal skin fibroblasts corneal collagen crosslinking |
| url | https://journal.transpl.ru/vtio/article/view/418 |
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