Leveraging in vitro and pharmacokinetic models to support bench to bedside investigation of XTMAB-16 as a novel pulmonary sarcoidosis treatment

Leveraging in vitro and pharmacokinetic models to support bench to bedside investigation of XTMAB-16 as a novel pulmonary sarcoidosis treatment

Background: Sarcoidosis is a chronic, multisystem inflammatory disorder characterized by non-caseating epithelioid granulomas; infiltration of mononuclear cells; and destruction of microarchitecture in the skin, eye, heart, and central nervous system, and the lung in >90% of cases. XTMAB-16 i...

Full description

Bibliographic Details
Main Authors: Elliot Offman, Noopur Singh, Mark W. Julian, Landon W. Locke, Sabahattin Bicer, Jonah Mitchell, Thomas Matthews, Kirsten Anderson, Elliott D. Crouser
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
sarcoidosis
XTMAB-16
TNFα
granuloma
population pharmacokinetic modeling
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1066454/full

Similar Items

Similar Items