Predictive factors of melanoma thickness
Abstract Background: Melanoma thickness is a relevant prognostic marker that is crucial for staging and its calculation relies on the histopathological examination. There is a risk of thickness underestimation with an incisional biopsy if the latter is not performed on a tumor area where the thickn...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Dermatologia
2022-09-01
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| Series: | Anais Brasileiros de Dermatologia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962022000500601&tlng=en |
| _version_ | 1811205498427408384 |
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| author | Ana Rita Carreiro Silva Ricardo José David Costa Vieira |
| author_facet | Ana Rita Carreiro Silva Ricardo José David Costa Vieira |
| author_sort | Ana Rita Carreiro Silva |
| collection | DOAJ |
| description | Abstract Background: Melanoma thickness is a relevant prognostic marker that is crucial for staging and its calculation relies on the histopathological examination. There is a risk of thickness underestimation with an incisional biopsy if the latter is not performed on a tumor area where the thickness is maximal. This occurrence may have an impact on a therapeutic decision, particularly regarding the excision margins and the need for sentinel lymph node biopsy. Objective: To assess the association between melanoma thickness and dermoscopic, demographic, epidemiological and clinical variables, aiming to identify predictive factors of thickness >1 mm. Methods: This was an observational and cross-sectional study, carried out on patients diagnosed with melanoma, from a single center over a time span of four years. Anatomopathological (thickness), dermoscopic, demographic, epidemiological, and clinical variables were collected. The associations between the variables with melanoma thickness were assessed. Results: A total of 119 patients were included. The presence of atypical vessels on the dermoscopic examination was an independent predictive factor of thickness >1 mm. Conversely, an atypical reticular pattern predicted melanoma thickness <1 mm. The presence of ephelides and a previous history of sunburn were also associated with melanomas thinner than 1 mm in the univariate analysis. Study limitations: The lack of data related to some variables and the absence of an optimal correlation between the dermoscopic and the anatomopathological examination constituted study limitations. Conclusion: An atypical vascular pattern on dermoscopy is associated with thickness >1 mm, helping with the choice of the optimal site to perform an incisional biopsy when an excisional biopsy is not feasible. |
| first_indexed | 2024-04-12T03:33:44Z |
| format | Article |
| id | doaj.art-d001c00de81c47bf88cbe9e85e927ee4 |
| institution | Directory Open Access Journal |
| issn | 0365-0596 |
| language | English |
| last_indexed | 2024-04-12T03:33:44Z |
| publishDate | 2022-09-01 |
| publisher | Sociedade Brasileira de Dermatologia |
| record_format | Article |
| series | Anais Brasileiros de Dermatologia |
| spelling | doaj.art-d001c00de81c47bf88cbe9e85e927ee42022-12-22T03:49:30ZengSociedade Brasileira de DermatologiaAnais Brasileiros de Dermatologia0365-05962022-09-0197560160510.1016/j.abd.2021.12.002Predictive factors of melanoma thicknessAna Rita Carreiro Silvahttps://orcid.org/0000-0001-7649-9950Ricardo José David Costa Vieirahttps://orcid.org/0000-0002-5914-9171Abstract Background: Melanoma thickness is a relevant prognostic marker that is crucial for staging and its calculation relies on the histopathological examination. There is a risk of thickness underestimation with an incisional biopsy if the latter is not performed on a tumor area where the thickness is maximal. This occurrence may have an impact on a therapeutic decision, particularly regarding the excision margins and the need for sentinel lymph node biopsy. Objective: To assess the association between melanoma thickness and dermoscopic, demographic, epidemiological and clinical variables, aiming to identify predictive factors of thickness >1 mm. Methods: This was an observational and cross-sectional study, carried out on patients diagnosed with melanoma, from a single center over a time span of four years. Anatomopathological (thickness), dermoscopic, demographic, epidemiological, and clinical variables were collected. The associations between the variables with melanoma thickness were assessed. Results: A total of 119 patients were included. The presence of atypical vessels on the dermoscopic examination was an independent predictive factor of thickness >1 mm. Conversely, an atypical reticular pattern predicted melanoma thickness <1 mm. The presence of ephelides and a previous history of sunburn were also associated with melanomas thinner than 1 mm in the univariate analysis. Study limitations: The lack of data related to some variables and the absence of an optimal correlation between the dermoscopic and the anatomopathological examination constituted study limitations. Conclusion: An atypical vascular pattern on dermoscopy is associated with thickness >1 mm, helping with the choice of the optimal site to perform an incisional biopsy when an excisional biopsy is not feasible.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962022000500601&tlng=enDermoscopyMelanomaSentinel lymph node biopsy |
| spellingShingle | Ana Rita Carreiro Silva Ricardo José David Costa Vieira Predictive factors of melanoma thickness Anais Brasileiros de Dermatologia Dermoscopy Melanoma Sentinel lymph node biopsy |
| title | Predictive factors of melanoma thickness |
| title_full | Predictive factors of melanoma thickness |
| title_fullStr | Predictive factors of melanoma thickness |
| title_full_unstemmed | Predictive factors of melanoma thickness |
| title_short | Predictive factors of melanoma thickness |
| title_sort | predictive factors of melanoma thickness |
| topic | Dermoscopy Melanoma Sentinel lymph node biopsy |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962022000500601&tlng=en |
| work_keys_str_mv | AT anaritacarreirosilva predictivefactorsofmelanomathickness AT ricardojosedavidcostavieira predictivefactorsofmelanomathickness |