Plasma and urine proteomics and gut microbiota analysis reveal potential factors affecting COVID-19 vaccination response
Summary: The efficacy of COVID-19 vaccination relies on the induction of neutralizing antibodies, which can vary among vaccine recipients. In this study, we investigated the potential factors affecting the neutralizing antibody response by combining plasma and urine proteomics and gut microbiota ana...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004224000725 |
| _version_ | 1797345945372852224 |
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| author | Changjiang Hu Weichao Hu Bo Tang Qiyu Bao Xingyu Jiang Li Tang He Wang Lijiao He Moyang Lv Yufeng Xiao Cheng Liu Xinzhe Li Yunyi Liu Jie Li Guiping Huang Zhen Dong Zhongjun Li Tiannan Guo Shiming Yang |
| author_facet | Changjiang Hu Weichao Hu Bo Tang Qiyu Bao Xingyu Jiang Li Tang He Wang Lijiao He Moyang Lv Yufeng Xiao Cheng Liu Xinzhe Li Yunyi Liu Jie Li Guiping Huang Zhen Dong Zhongjun Li Tiannan Guo Shiming Yang |
| author_sort | Changjiang Hu |
| collection | DOAJ |
| description | Summary: The efficacy of COVID-19 vaccination relies on the induction of neutralizing antibodies, which can vary among vaccine recipients. In this study, we investigated the potential factors affecting the neutralizing antibody response by combining plasma and urine proteomics and gut microbiota analysis. We found that activation of the LXR/FXR pathway in plasma was associated with the production of ACE2-RBD-inhibiting antibodies, while urine proteins related to complement system, acute phase response signaling, LXR/FXR, and STAT3 pathways were correlated with neutralizing antibody production. Moreover, we observed a correlation between the gut microbiota and plasma and urine proteins, as well as the vaccination response. Based on the above data, we built a predictive model for vaccination response (AUC = 0.85). Our study provides insights into characteristic plasma and urine proteins and gut microbiota associated with the ACE2-RBD-inhibiting antibodies, which could benefit our understanding of the host response to COVID-19 vaccination. |
| first_indexed | 2024-03-08T11:26:10Z |
| format | Article |
| id | doaj.art-d004e6eb5ee443cd81b5a1c15f1019a9 |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-08T11:26:10Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-d004e6eb5ee443cd81b5a1c15f1019a92024-01-26T05:34:21ZengElsevieriScience2589-00422024-02-01272108851Plasma and urine proteomics and gut microbiota analysis reveal potential factors affecting COVID-19 vaccination responseChangjiang Hu0Weichao Hu1Bo Tang2Qiyu Bao3Xingyu Jiang4Li Tang5He Wang6Lijiao He7Moyang Lv8Yufeng Xiao9Cheng Liu10Xinzhe Li11Yunyi Liu12Jie Li13Guiping Huang14Zhen Dong15Zhongjun Li16Tiannan Guo17Shiming Yang18Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China; iMarkerlab, Westlake Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang Province, China; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, Zhejiang Province, China; Research Center for Industries of the Future, Westlake University, 600 Dunyu Road, Hangzhou 310030, Zhejiang, China; Center for Infectious Disease Research, Westlake University, 18 Shilongshan Road, Hangzhou 310024, Zhejiang, ChinaDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China; iMarkerlab, Westlake Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang Province, China; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, Zhejiang Province, China; Research Center for Industries of the Future, Westlake University, 600 Dunyu Road, Hangzhou 310030, Zhejiang, China; Center for Infectious Disease Research, Westlake University, 18 Shilongshan Road, Hangzhou 310024, Zhejiang, ChinaDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, ChinaDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, ChinaLaboratory Medicine Center, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, ChinaDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, ChinaiMarkerlab, Westlake Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang Province, China; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, Zhejiang Province, China; Research Center for Industries of the Future, Westlake University, 600 Dunyu Road, Hangzhou 310030, Zhejiang, China; Center for Infectious Disease Research, Westlake University, 18 Shilongshan Road, Hangzhou 310024, Zhejiang, ChinaDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, ChinaDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, ChinaDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, ChinaDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, ChinaDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, ChinaDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, ChinaDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, ChinaDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, ChinaiMarkerlab, Westlake Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang Province, China; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, Zhejiang Province, China; Research Center for Industries of the Future, Westlake University, 600 Dunyu Road, Hangzhou 310030, Zhejiang, China; Center for Infectious Disease Research, Westlake University, 18 Shilongshan Road, Hangzhou 310024, Zhejiang, China; Corresponding authorLaboratory Medicine Center, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China; Corresponding authoriMarkerlab, Westlake Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang Province, China; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, Zhejiang Province, China; Research Center for Industries of the Future, Westlake University, 600 Dunyu Road, Hangzhou 310030, Zhejiang, China; Center for Infectious Disease Research, Westlake University, 18 Shilongshan Road, Hangzhou 310024, Zhejiang, China; Corresponding authorDepartment of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China; Corresponding authorSummary: The efficacy of COVID-19 vaccination relies on the induction of neutralizing antibodies, which can vary among vaccine recipients. In this study, we investigated the potential factors affecting the neutralizing antibody response by combining plasma and urine proteomics and gut microbiota analysis. We found that activation of the LXR/FXR pathway in plasma was associated with the production of ACE2-RBD-inhibiting antibodies, while urine proteins related to complement system, acute phase response signaling, LXR/FXR, and STAT3 pathways were correlated with neutralizing antibody production. Moreover, we observed a correlation between the gut microbiota and plasma and urine proteins, as well as the vaccination response. Based on the above data, we built a predictive model for vaccination response (AUC = 0.85). Our study provides insights into characteristic plasma and urine proteins and gut microbiota associated with the ACE2-RBD-inhibiting antibodies, which could benefit our understanding of the host response to COVID-19 vaccination.http://www.sciencedirect.com/science/article/pii/S2589004224000725Health sciencesImmunityMicrobiologyExperimental models in systems biologyProteomics |
| spellingShingle | Changjiang Hu Weichao Hu Bo Tang Qiyu Bao Xingyu Jiang Li Tang He Wang Lijiao He Moyang Lv Yufeng Xiao Cheng Liu Xinzhe Li Yunyi Liu Jie Li Guiping Huang Zhen Dong Zhongjun Li Tiannan Guo Shiming Yang Plasma and urine proteomics and gut microbiota analysis reveal potential factors affecting COVID-19 vaccination response iScience Health sciences Immunity Microbiology Experimental models in systems biology Proteomics |
| title | Plasma and urine proteomics and gut microbiota analysis reveal potential factors affecting COVID-19 vaccination response |
| title_full | Plasma and urine proteomics and gut microbiota analysis reveal potential factors affecting COVID-19 vaccination response |
| title_fullStr | Plasma and urine proteomics and gut microbiota analysis reveal potential factors affecting COVID-19 vaccination response |
| title_full_unstemmed | Plasma and urine proteomics and gut microbiota analysis reveal potential factors affecting COVID-19 vaccination response |
| title_short | Plasma and urine proteomics and gut microbiota analysis reveal potential factors affecting COVID-19 vaccination response |
| title_sort | plasma and urine proteomics and gut microbiota analysis reveal potential factors affecting covid 19 vaccination response |
| topic | Health sciences Immunity Microbiology Experimental models in systems biology Proteomics |
| url | http://www.sciencedirect.com/science/article/pii/S2589004224000725 |
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