Asymmetric synthesis of γ-branched amines via rhodium-catalyzed reductive amination
Biologically active compounds often contain a chiral centre in proximity of amine groups. Here, the authors developed a strategy involving asymmetric isomerization of allylic amines, enamine exchange and chemoselective reduction for the one-pot highly enantioselective synthesis of gamma-branched ami...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2018-03-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-03535-y |
| _version_ | 1818419878424477696 |
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| author | Zhao Wu Summer D. Laffoon Kami L. Hull |
| author_facet | Zhao Wu Summer D. Laffoon Kami L. Hull |
| author_sort | Zhao Wu |
| collection | DOAJ |
| description | Biologically active compounds often contain a chiral centre in proximity of amine groups. Here, the authors developed a strategy involving asymmetric isomerization of allylic amines, enamine exchange and chemoselective reduction for the one-pot highly enantioselective synthesis of gamma-branched amines. |
| first_indexed | 2024-12-14T12:45:34Z |
| format | Article |
| id | doaj.art-d0056dab2aed43fea5991c0676edf1b0 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T12:45:34Z |
| publishDate | 2018-03-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d0056dab2aed43fea5991c0676edf1b02022-12-21T23:00:48ZengNature PortfolioNature Communications2041-17232018-03-01911710.1038/s41467-018-03535-yAsymmetric synthesis of γ-branched amines via rhodium-catalyzed reductive aminationZhao Wu0Summer D. Laffoon1Kami L. Hull2Department of Chemistry, University of Illinois at Urbana-ChampaignDepartment of Chemistry, University of Illinois at Urbana-ChampaignDepartment of Chemistry, University of Illinois at Urbana-ChampaignBiologically active compounds often contain a chiral centre in proximity of amine groups. Here, the authors developed a strategy involving asymmetric isomerization of allylic amines, enamine exchange and chemoselective reduction for the one-pot highly enantioselective synthesis of gamma-branched amines.https://doi.org/10.1038/s41467-018-03535-y |
| spellingShingle | Zhao Wu Summer D. Laffoon Kami L. Hull Asymmetric synthesis of γ-branched amines via rhodium-catalyzed reductive amination Nature Communications |
| title | Asymmetric synthesis of γ-branched amines via rhodium-catalyzed reductive amination |
| title_full | Asymmetric synthesis of γ-branched amines via rhodium-catalyzed reductive amination |
| title_fullStr | Asymmetric synthesis of γ-branched amines via rhodium-catalyzed reductive amination |
| title_full_unstemmed | Asymmetric synthesis of γ-branched amines via rhodium-catalyzed reductive amination |
| title_short | Asymmetric synthesis of γ-branched amines via rhodium-catalyzed reductive amination |
| title_sort | asymmetric synthesis of γ branched amines via rhodium catalyzed reductive amination |
| url | https://doi.org/10.1038/s41467-018-03535-y |
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