Ganciclovir and Its Hemocompatible More Lipophilic Derivative Can Enhance the Apoptotic Effects of Methotrexate by Inhibiting Breast Cancer Resistance Protein (BCRP)

Ganciclovir and Its Hemocompatible More Lipophilic Derivative Can Enhance the Apoptotic Effects of Methotrexate by Inhibiting Breast Cancer Resistance Protein (BCRP)

Efflux transporters, namely ATP-binding cassette (ABC), are one of the primary reasons for cancer chemoresistance and the clinical failure of chemotherapy. Ganciclovir (GCV) is an antiviral agent used in herpes simplex virus thymidine kinase (HSV-TK) gene therapy. In this therapy, HSV-TK gene is del...

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Bibliographic Details
Main Authors: Magdalena Markowicz-Piasecka, Johanna Huttunen, Ahmed Montaser, Santosh Kumar Adla, Seppo Auriola, Marko Lehtonen, Kristiina M. Huttunen
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:International Journal of Molecular Sciences
Subjects:
breast cancer resistant protein (BCRP)
ganciclovir (GCV)
methotrexate (MTX)
MCF-7/MDA-MB-231 human breast cancer cells
multidrug resistance (MDR)
Online Access:https://www.mdpi.com/1422-0067/22/14/7727

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