The VEGF-Receptor Inhibitor Axitinib Impairs Dendritic Cell Phenotype and Function.

The VEGF-Receptor Inhibitor Axitinib Impairs Dendritic Cell Phenotype and Function.

Inhibitors of VEGF receptor (VEGFR) signaling such as sorafenib and sunitinib that are currently used in the treatment of malignant diseases have been shown to affect immunological responses by inhibition of the function of antigen presenting cells and T lymphocytes. The VEGFR-inhibitor axitinib has...

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Bibliographic Details
Main Authors: Annkristin Heine, Stefanie Andrea Erika Held, Solveig Nora Daecke, Kati Riethausen, Philipp Kotthoff, Chrystel Flores, Christian Kurts, Peter Brossart
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4456373?pdf=render

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