Comparing the effectiveness of oral versus intravenous antibiotics in the prophylaxis of wound infection in hand laceration
Objective: Hand lacerations are among the most frequent causes of visiting emergency departments (EDs). Wound infection is one of its complications. There is still an ongoing disagreement on the administration of oral versus intravenous (IV) antibiotics (ABs). The objective of this study is to compa...
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| Format: | Article |
| Language: | English |
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Kerman University of Medical Sciences
2023-01-01
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| Series: | Journal of Emergency Practice and Trauma |
| Subjects: | |
| Online Access: | http://www.jept.ir/article_92104_e09eb5b705ba3ac217a7b164ac7c3f38.pdf |
| _version_ | 1797828076630966272 |
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| author | Mehdi Momeni Elnaz Vahidi Neda Karimi Tafti Zeinab Naderpour Javad Seyedhosseini Morteza Saeedi |
| author_facet | Mehdi Momeni Elnaz Vahidi Neda Karimi Tafti Zeinab Naderpour Javad Seyedhosseini Morteza Saeedi |
| author_sort | Mehdi Momeni |
| collection | DOAJ |
| description | Objective: Hand lacerations are among the most frequent causes of visiting emergency departments (EDs). Wound infection is one of its complications. There is still an ongoing disagreement on the administration of oral versus intravenous (IV) antibiotics (ABs). The objective of this study is to compare the effectiveness of oral versus IV ABs in preventing wound infection of hand lacerations.
Methods: In this double-blind, randomized clinical trial, we enrolled all patients with hand lacerations (based on the inclusion criteria) during 6 months in the EDs of 2 tertiary referral centers. Convenient sampling was done. Finally, in the first group, 382 patients received oral AB (two 500 mg cephalexin capsules) and the other 382 patients in the second group received IV AB (1 gr IV cefazolin) before wound management. Both groups were followed and received oral cephalexin during 48 hours after suturing. Rates of wound infection and different complications were compared between the two groups. T-test, Mann-Whitney U test, Chi square and Fisher analysis were used.
Results: Both groups had the same age and gender distribution rate (79.8% of males with the mean age of 30.8 years in the first group, and 83.5% of males with the mean age of 32.6 years in the second group (P=0.19 and 0.39, respectively). In our study, wound infection developed in 2.6% and 1.8% of patients in the first and second groups, respectively (P=0.46).
Conclusion: Based on the results of this study, oral and IV ABs were not significantly
different in terms of preventing wound infection. |
| first_indexed | 2024-04-09T12:58:35Z |
| format | Article |
| id | doaj.art-d00a6571d79c4ee79ff05968aa520070 |
| institution | Directory Open Access Journal |
| issn | 2383-4544 |
| language | English |
| last_indexed | 2024-04-09T12:58:35Z |
| publishDate | 2023-01-01 |
| publisher | Kerman University of Medical Sciences |
| record_format | Article |
| series | Journal of Emergency Practice and Trauma |
| spelling | doaj.art-d00a6571d79c4ee79ff05968aa5200702023-05-13T10:14:25ZengKerman University of Medical SciencesJournal of Emergency Practice and Trauma2383-45442023-01-01911318https://doi.org/10.34172/jept.2022.19Comparing the effectiveness of oral versus intravenous antibiotics in the prophylaxis of wound infection in hand lacerationMehdi Momeni0https://orcid.org/0000-0001-7816-8733Elnaz Vahidi1https://orcid.org/0000-0002-4580-1456Neda Karimi Tafti2https://orcid.org/0000-0002-6056-5041Zeinab Naderpour3https://orcid.org/0000-0001-7185-1177Javad Seyedhosseini4https://orcid.org/0000-0002-9131-9732 Morteza Saeedi5https://orcid.org/0000-0001-8416-6048Emergency Medicine Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranEmergency Medicine Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranEmergency Medicine Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranInternal Medicine Department, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranEmergency Medicine Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranEmergency Medicine Research Center, Shariati Hospital, Tehran University of Medical Sciences, Tehran, IranObjective: Hand lacerations are among the most frequent causes of visiting emergency departments (EDs). Wound infection is one of its complications. There is still an ongoing disagreement on the administration of oral versus intravenous (IV) antibiotics (ABs). The objective of this study is to compare the effectiveness of oral versus IV ABs in preventing wound infection of hand lacerations. Methods: In this double-blind, randomized clinical trial, we enrolled all patients with hand lacerations (based on the inclusion criteria) during 6 months in the EDs of 2 tertiary referral centers. Convenient sampling was done. Finally, in the first group, 382 patients received oral AB (two 500 mg cephalexin capsules) and the other 382 patients in the second group received IV AB (1 gr IV cefazolin) before wound management. Both groups were followed and received oral cephalexin during 48 hours after suturing. Rates of wound infection and different complications were compared between the two groups. T-test, Mann-Whitney U test, Chi square and Fisher analysis were used. Results: Both groups had the same age and gender distribution rate (79.8% of males with the mean age of 30.8 years in the first group, and 83.5% of males with the mean age of 32.6 years in the second group (P=0.19 and 0.39, respectively). In our study, wound infection developed in 2.6% and 1.8% of patients in the first and second groups, respectively (P=0.46). Conclusion: Based on the results of this study, oral and IV ABs were not significantly different in terms of preventing wound infection.http://www.jept.ir/article_92104_e09eb5b705ba3ac217a7b164ac7c3f38.pdfhand lacerationoral antibioticintravenous antibioticwound infection |
| spellingShingle | Mehdi Momeni Elnaz Vahidi Neda Karimi Tafti Zeinab Naderpour Javad Seyedhosseini Morteza Saeedi Comparing the effectiveness of oral versus intravenous antibiotics in the prophylaxis of wound infection in hand laceration Journal of Emergency Practice and Trauma hand laceration oral antibiotic intravenous antibiotic wound infection |
| title | Comparing the effectiveness of oral versus intravenous antibiotics in the prophylaxis of wound infection in hand laceration |
| title_full | Comparing the effectiveness of oral versus intravenous antibiotics in the prophylaxis of wound infection in hand laceration |
| title_fullStr | Comparing the effectiveness of oral versus intravenous antibiotics in the prophylaxis of wound infection in hand laceration |
| title_full_unstemmed | Comparing the effectiveness of oral versus intravenous antibiotics in the prophylaxis of wound infection in hand laceration |
| title_short | Comparing the effectiveness of oral versus intravenous antibiotics in the prophylaxis of wound infection in hand laceration |
| title_sort | comparing the effectiveness of oral versus intravenous antibiotics in the prophylaxis of wound infection in hand laceration |
| topic | hand laceration oral antibiotic intravenous antibiotic wound infection |
| url | http://www.jept.ir/article_92104_e09eb5b705ba3ac217a7b164ac7c3f38.pdf |
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