Affected cell types for hundreds of Mendelian diseases revealed by analysis of human and mouse single-cell data

Affected cell types for hundreds of Mendelian diseases revealed by analysis of human and mouse single-cell data

Mendelian diseases tend to manifest clinically in certain tissues, yet their affected cell types typically remain elusive. Single-cell expression studies showed that overexpression of disease-associated genes may point to the affected cell types. Here, we developed a method that infers disease-affec...

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Bibliographic Details
Main Authors: Idan Hekselman, Assaf Vital, Maya Ziv-Agam, Lior Kerber, Ido Yairi, Esti Yeger-Lotem
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-01-01
Series:eLife
Subjects:
single-cell transcriptomics
Mendelian diseases
cell-type selectivity
data integration
tissue selectivity
Online Access:https://elifesciences.org/articles/84613

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