Nogo-A antibody delivery through the olfactory mucosa mitigates experimental autoimmune encephalomyelitis in the mouse CNS

Nogo-A antibody delivery through the olfactory mucosa mitigates experimental autoimmune encephalomyelitis in the mouse CNS

Abstract Systemic administration of Nogo-A-neutralizing antibody ameliorates experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. However, the blood-brain barrier (BBB) is a major obstacle limiting the passage of systemically applied antibody to the CNS. To bypass...

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Bibliographic Details
Main Authors: Vincent Pernet, Sandrine Joly, Sebastian Spiegel, Ivo Meli, Sherif Idriss, Frank Maigler, Julius Baya Mdzomba, Anna K. Roenneke, Alessandra Franceschini, Ludovico Silvestri, Francesco S. Pavone, Martino Calamai, Katharina Schindowski, Andrew Chan
Format: Article
Language:English
Published: Nature Publishing Group 2023-08-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-023-01588-7

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https://doi.org/10.1038/s41420-023-01588-7

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