Pharmacological and toxicity effects of Zhumeria majdae and its bioactive constituents: A review
Zhumeria majdae Rech. F. & Wendelbo. traditionally has been used in several remedies, as a carminative agent especially for children, as an antiseptic agent, and it is used in treating diarrhea, stomach irritations, headaches, colds, convulsions, spasms, dysmenorrhea, and healing wounds. Accordi...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2023-03-01
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| Series: | Iranian Journal of Basic Medical Sciences |
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| Online Access: | https://ijbms.mums.ac.ir/article_21477_a68d368168497fd9328f861115b9f148.pdf |
| _version_ | 1797849002661642240 |
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| author | Kimia Khosravi Arman Monajemi Mamaghani Hossein Hosseinzadeh |
| author_facet | Kimia Khosravi Arman Monajemi Mamaghani Hossein Hosseinzadeh |
| author_sort | Kimia Khosravi |
| collection | DOAJ |
| description | Zhumeria majdae Rech. F. & Wendelbo. traditionally has been used in several remedies, as a carminative agent especially for children, as an antiseptic agent, and it is used in treating diarrhea, stomach irritations, headaches, colds, convulsions, spasms, dysmenorrhea, and healing wounds. According to clinical studies, it is highly effective for reducing inflammation and pain, treating bacterial and fungal infections, morphine tolerance, morphine dependence, withdrawal syndrome symptoms, convulsions, and diabetes. The goal of this review is to find therapeutic opportunities by analyzing the traditional uses and pharmacological effects of the chemical constituents of Z. majdae.The information on Z. majdae in this review was gathered from scientific databases or search engines (PubMed, Wiley Online Library, Scopus, SID, Google Scholar, and Microsoft Academic). The literature cited in this review dates from 1992 to 2021. Several bioactive components including linalool, camphor, manool, and bioactive diterpenoids are presen in different parts of Z. majdae. Various properties were observed such as antioxidant, antinociceptive, anti-inflammatory, antimicrobial, antiviral, larvicidal, anticonvulsant, antidiabetic, and anticancer properties. Also, the effect of Z. majdae on morphine tolerance, morphine dependence, and withdrawal syndrome as well as its toxicology has been established. Although there are in vitro and animal studies on several pharmacological effects of Z. majdae, the lack of clinical studies is significant. Therefore, further clinical trials should be performed to confirm the in vitro and animal findings. |
| first_indexed | 2024-04-09T18:36:48Z |
| format | Article |
| id | doaj.art-d00e2a1476b84741975d1e9383d2b1dd |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-04-09T18:36:48Z |
| publishDate | 2023-03-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-d00e2a1476b84741975d1e9383d2b1dd2023-04-11T09:30:50ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742023-03-0126325526810.22038/ijbms.2022.64967.1430421477Pharmacological and toxicity effects of Zhumeria majdae and its bioactive constituents: A reviewKimia Khosravi0Arman Monajemi Mamaghani1Hossein Hosseinzadeh2Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranDepartment of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IranZhumeria majdae Rech. F. & Wendelbo. traditionally has been used in several remedies, as a carminative agent especially for children, as an antiseptic agent, and it is used in treating diarrhea, stomach irritations, headaches, colds, convulsions, spasms, dysmenorrhea, and healing wounds. According to clinical studies, it is highly effective for reducing inflammation and pain, treating bacterial and fungal infections, morphine tolerance, morphine dependence, withdrawal syndrome symptoms, convulsions, and diabetes. The goal of this review is to find therapeutic opportunities by analyzing the traditional uses and pharmacological effects of the chemical constituents of Z. majdae.The information on Z. majdae in this review was gathered from scientific databases or search engines (PubMed, Wiley Online Library, Scopus, SID, Google Scholar, and Microsoft Academic). The literature cited in this review dates from 1992 to 2021. Several bioactive components including linalool, camphor, manool, and bioactive diterpenoids are presen in different parts of Z. majdae. Various properties were observed such as antioxidant, antinociceptive, anti-inflammatory, antimicrobial, antiviral, larvicidal, anticonvulsant, antidiabetic, and anticancer properties. Also, the effect of Z. majdae on morphine tolerance, morphine dependence, and withdrawal syndrome as well as its toxicology has been established. Although there are in vitro and animal studies on several pharmacological effects of Z. majdae, the lack of clinical studies is significant. Therefore, further clinical trials should be performed to confirm the in vitro and animal findings.https://ijbms.mums.ac.ir/article_21477_a68d368168497fd9328f861115b9f148.pdfanalgesicsanticonvulsantsanti-infective agentsanti-inflammatory agentscamphorlinaloolmorphine dependencezhumeria majdae |
| spellingShingle | Kimia Khosravi Arman Monajemi Mamaghani Hossein Hosseinzadeh Pharmacological and toxicity effects of Zhumeria majdae and its bioactive constituents: A review Iranian Journal of Basic Medical Sciences analgesics anticonvulsants anti-infective agents anti-inflammatory agents camphor linalool morphine dependence zhumeria majdae |
| title | Pharmacological and toxicity effects of Zhumeria majdae and its bioactive constituents: A review |
| title_full | Pharmacological and toxicity effects of Zhumeria majdae and its bioactive constituents: A review |
| title_fullStr | Pharmacological and toxicity effects of Zhumeria majdae and its bioactive constituents: A review |
| title_full_unstemmed | Pharmacological and toxicity effects of Zhumeria majdae and its bioactive constituents: A review |
| title_short | Pharmacological and toxicity effects of Zhumeria majdae and its bioactive constituents: A review |
| title_sort | pharmacological and toxicity effects of zhumeria majdae and its bioactive constituents a review |
| topic | analgesics anticonvulsants anti-infective agents anti-inflammatory agents camphor linalool morphine dependence zhumeria majdae |
| url | https://ijbms.mums.ac.ir/article_21477_a68d368168497fd9328f861115b9f148.pdf |
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