Detection of Mouse Cytomegalovirus in Adenocarcinoma Bearing Razi/A Mice: Molecular and Pathological Studies
Despite a lot of research, the etiology and progression of breast cancer remain incompletely understood. Recently, human cytomegalovirus (HCMV) was reported as a risk factor for breast cancer. The aim of this study was to know whether breast cancer could be caused by cytomegalovirus or not? In this...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Razi Vaccine and Serum Research Institute
2014-05-01
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| Series: | Archives of Razi Institute |
| Subjects: | |
| Online Access: | http://www.archrazi.com/browse.php?a_id=473&sid=1&slc_lang=en |
| Summary: | Despite a lot of research, the etiology and progression of breast cancer remain incompletely understood. Recently, human cytomegalovirus (HCMV) was reported as a risk factor for breast cancer. The aim of this study was to know whether breast cancer could be caused by cytomegalovirus or not? In this experiment seventeen samples of RAZI/A mice with spontaneous breast cancer were being gathered from laboratory animals department. Histopathology and polymerase chain reaction (PCR) tests were done on breast tissue samples. Formalin-fixed tissue specimens were obtained from mouse normal breast tissues (n:17) and mouse mammary tumors (n:17). Detection of mouse cytomegalovirus was done by the pUC57-MCK-2 plasmid. Our histopathology data showed Adenocarcinoma type B in mouse with mammary tumors. There was a significant difference between mice with spontaneous breast cancer and control by Pearson Chi-Square (Value: 17.000b and P=0.000). More research will be needed to determine the effect of cytomegalovirus on breast cancer. |
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| ISSN: | 0365-3439 2008-9872 |